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Systemic Corticosteroid
Aka: Systemic Corticosteroid, Corticosteroid, Betamethasone, Dexamethasone, Cortisone, Hydrocortisone, Methylprednisolone, Prednisolone, Prednisone- See Also
- Dosing: Adult
- Betamethasone (Celestone) 0.5 to 0.9 mg IM/PO qd
- Cortisone (Cortone) 25-300 mg PO qd
- Dexamethasone (Decadron) 0.75-9 mg PO/IM/IV divided q6h
- Hydrocortisone (Cortef)
- Parenteral: 100 to 150 mg IV/IM q2-6 hours prn
- Oral: 20 to 240 mg/day PO in divided dosing
- Methylprednisolone
- Parenteral (Solu-Medrol) 10 to 125 mg IV/IM
- Oral (Medrol) 4 to 48 mg PO qd
- Medrol Dose pack: tapers from 24 to 0 PO over 7 days
- Triamcinolone (Aristocort, Kenalog) 4 to 48 mg PO/IM qd
- Prednisolone (Prelone) 5-60 mg PO/IV/IM qd
- Prednisone (Deltasone) 5-60 mg PO qd
- Rayos (delayed release version of Prednisone)
- Marketed to reduce morning inflammation in Rheumatoid Arthritis
- Taken at 10 pm with intended release starting at 2 am
- Unlikely to add significant benefit for the cost (more than $200 for thirty 5 mg tabs)
- (2012) Prescr Lett 19(12): 69
- Dosing: Child
- Methylprednisolone (Solu-Medrol)
- Dose: 1-2 mg/kg/dose PO/IV/IM q6h up to 125 mg/dose
- Prednisolone (Prelone)
- Dose: 1-2 mg/kg/dose PO qd to bid up to 60 mg/day
- Maximum: 60 mg per day
- Preparations
- Syrup: 15 mg/5 ml
- Liquid: 5 mg/5 ml
- Methylprednisolone (Solu-Medrol)
- Agents: Overall potency (equivalent dosages)
- High potency
- Betamethasone 0.6 to 0.75 mg
- Dexamethasone 0.75 mg
- Medium potency
- Methylprednisolone 4 mg
- Triamcinolone 4 mg
- Prednisolone 5 mg
- Prednisone 5 mg
- Low potency
- Hydrocortisone 20 mg
- Cortisone 25 mg
- High potency
- Agents: Relative anti-inflammatory potency
- High anti-inflammatory potency
- Betamethasone 20-30
- Dexamethasone 20-30
- Medium anti-inflammatory potency
- Methylprednisolone 5
- Triamcinolone 5
- Prednisolone 4
- Prednisone 4
- Low anti-inflammatory potency
- Hydrocortisone 1
- Cortisone 0.8
- High anti-inflammatory potency
- Agents: Relative Mineralocorticoid Potency
- Mineralocorticoid Activity
- Cortisone 2
- Hydrocortisone 2
- Prednisolone 1
- Prednisone 1
- No Mineralocorticoid Activity
- Betamethasone
- Dexamethasone
- Methylprednisolone
- Triamcinolone
- Mineralocorticoid Activity
- Agents: Half Life
- Long half-life (36-54 hours)
- Betamethasone
- Dexamethasone
- Medium half-life (18-36 hours)
- Methylprednisolone
- Prednisolone
- Prednisone
- Triamcinolone
- Short half-life (8-12 hours)
- Cortisone
- Hydrocortisone
- Long half-life (36-54 hours)
- Adverse Effects: Long-term Corticosteroids
- Corticosteroid Associated Osteoporosis
- Corticosteroid Myopathy
- Emotional lability (depression or Hypomania)
- Motor restlessness
- Insomnia
- Hypertension
- Iatrogenic Diabetes Mellitus
- Hyperlipidemia
- Fluid retention
- Osteonecrosis of the hip
- Prevention of Corticosteroid complications
- References
| Medication Costs | ||
|---|---|---|
| NEO/POLYMX/DEXAMETHASONE (on 2/10/2012 at Target.com) | ||
| NEO/POLYMX/DEXAMETHASONE 0.1% OphthalmicOintment | #30 for $4.00 | ($0.13/unit) |
| NEO/POLYMX/DEXAMETHASONE 0.1% Ophthalmic Suspension | #30 for $4.00 | ($0.13/unit) |
| DEXAMETHASONE . (on 2/10/2012 at Target.com) | ||
| DEXAMETHASONE .75 MG Tablet | #30 for $4.00 | ($0.13/unit) |
| DEXAMETHASONE (on 2/10/2012 at Target.com) | ||
| DEXAMETHASONE 0.5 MG Tablet | #30 for $4.00 | ($0.13/unit) |
| DEXAMETHASONE 4 MG Tablet | #30 for $4.00 | ($0.13/unit) |
| HYDROCORTISONE AC (on 2/10/2012 at Target.com) | ||
| HYDROCORTISONE AC 25 MG Suppository | #30 for $4.00 | ($0.13/unit) |
| HYDROCORTISONE (on 2/10/2012 at Target.com) | ||
| HYDROCORTISONE 1% Cream | #30 for $4.00 | ($0.13/unit) |
| HYDROCORTISONE 2.5% Cream | #30 for $4.00 | ($0.13/unit) |
| PREDNISONE (on 2/10/2012 at Target.com) | ||
| PREDNISONE 2.5 MG Tablet | #30 for $4.00 | ($0.13/unit) |
| PREDNISONE 5 MG Tablet | #30 for $4.00 | ($0.13/unit) |
| PREDNISONE 10 MG Tablet | #30 for $4.00 | ($0.13/unit) |
| PREDNISONE 20 MG Tablet | #30 for $4.00 | ($0.13/unit) |
| Betamethasone Valerate (on 2/9/2012 at DrugStore.com) | ||
| Betamethasone Valerate 0.1% Ointment 15gm Tube | #1 for $25.99 | ($25.99/unit) |
| Betamethasone Valerate 0.1% Cream 15gm Tube | #1 for $22.99 | ($22.99/unit) |
| Betamethasone Valerate 0.1% Cream 45gm Tube | #1 for $39.99 | ($39.99/unit) |
| Betamethasone Valerate 0.1% Ointment 45gm Tube | #1 for $40.99 | ($40.99/unit) |
| Betamethasone Valerate 0.1% Lotion 60ml Bottle | #1 for $57.99 | ($57.99/unit) |
| Betamethasone Dipropionate Aug (on 2/9/2012 at DrugStore.com) | ||
| Betamethasone Dipropionate Aug 0.05% Cream 15gm Tube | #1 for $34.99 | ($34.99/unit) |
| Betamethasone Dipropionate Aug 0.05% Lotion 30ml Bottle | #1 for $52.99 | ($52.99/unit) |
| Betamethasone Dipropionate Aug 0.05% Lotion 60ml Bottle | #1 for $90.99 | ($90.99/unit) |
| Betamethasone Dipropionate Aug 0.05% Ointment 15gm Tube | #1 for $59.99 | ($59.99/unit) |
| Betamethasone Dipropionate Aug 0.05% Ointment 45gm Tube | #1 for $109.99 | ($109.99/unit) |
| Betamethasone Dipropionate Aug 0.05% Cream 50gm Tube | #1 for $64.99 | ($64.99/unit) |
| Betamethasone Dipropionate Aug 0.05% Gel 15gm Tube | #1 for $39.99 | ($39.99/unit) |
| Betamethasone Dipropionate Aug 0.05% Gel 50gm Tube | #1 for $79.99 | ($79.99/unit) |
| Betamethasone Dipropionate (on 2/9/2012 at DrugStore.com) | ||
| Betamethasone Dipropionate 0.05% Cream 15gm Tube | #1 for $37.99 | ($37.99/unit) |
| Betamethasone Dipropionate 0.05% Cream 45gm Tube | #1 for $63.99 | ($63.99/unit) |
| Betamethasone Dipropionate 0.05% Ointment 15gm Tube | #1 for $49.99 | ($49.99/unit) |
| Betamethasone Dipropionate 0.05% Ointment 45gm Tube | #1 for $75.99 | ($75.99/unit) |
| Betamethasone Dipropionate 0.05% Lotion 60ml Bottle | #1 for $48.99 | ($48.99/unit) |
| Clotrimazole-Betamethasone (on 2/9/2012 at DrugStore.com) | ||
| Clotrimazole-Betamethasone 1-0.05% Lotion 30ml Bottle | #1 for $73.99 | ($73.99/unit) |
| Clotrimazole-Betamethasone 1-0.05% Cream 15gm Tube | #1 for $28.99 | ($28.99/unit) |
| Dexamethasone (on 2/9/2012 at DrugStore.com) | ||
| Dexamethasone 0.5mg Tablets | #30 for $12.99 | ($0.43/unit) |
| Dexamethasone 0.75mg Tablets | #30 for $13.99 | ($0.47/unit) |
| Dexamethasone 1mg Tablets | #30 for $19.99 | ($0.67/unit) |
| Dexamethasone 1.5mg Tablets | #30 for $12.99 | ($0.43/unit) |
| Dexamethasone 2mg Tablets | #30 for $21.99 | ($0.73/unit) |
| Dexamethasone 4mg Tablets | #90 for $21.99 | ($0.24/unit) |
| Dexamethasone 6mg Tablets | #30 for $22.99 | ($0.77/unit) |
| Dexamethasone 0.5mg/5ml Elixir | #120 for $49.99 | ($0.42/unit) |
| Dexamethasone Sodium Phosphate (on 2/9/2012 at DrugStore.com) | ||
| Dexamethasone Sodium Phosphate 4mg/ml Solution 1ml Vial | #1 for $11.99 | ($11.99/unit) |
| Dexamethasone Sodium Phosphate 4mg/ml 1 Vial = 5ml | #5 for $19.99 | ($4.00/unit) |
| Dexamethasone Sodium Phosphate 4mg/ml Solution 30ml Vial | #1 for $16.99 | ($16.99/unit) |
| Dexamethasone Sodium Phosphate 0.1% Solution 5ml Bottle | #1 for $27.99 | ($27.99/unit) |
| Dexamethasone Sodium Phosphate 4mg/ml Solution 5ml Vial | #1 for $13.99 | ($13.99/unit) |
| Dexamethasone Sodium Phosphate 4mg/ml Solution (1 Box = 25x1ml Vials) | #1 for $37.99 | ($37.99/unit) |
| Tobramycin-Dexamethasone (on 2/9/2012 at DrugStore.com) | ||
| Tobramycin-Dexamethasone 0.3-0.1% Suspension 5ml Bottle | #1 for $69.99 | ($69.99/unit) |
| Tobramycin-Dexamethasone 0.3-0.1% Suspension 10ml Bottle | #1 for $129.98 | ($129.98/unit) |
| Tobramycin-Dexamethasone 0.3-0.1% Suspension 2.5ml Bottle | #1 for $35.99 | ($35.99/unit) |
| Fludrocortisone Acetate (on 2/9/2012 at DrugStore.com) | ||
| Fludrocortisone Acetate 0.1mg Tablets | #30 for $24.99 | ($0.83/unit) |
| Cortisone Acetate (on 2/9/2012 at DrugStore.com) | ||
| Cortisone Acetate 25mg Tablets | #30 for $19.99 | ($0.67/unit) |
| Hydrocortisone (on 2/9/2012 at DrugStore.com) | ||
| Hydrocortisone 0.5% Cream 28.35gm Tube | #1 for $13.99 | ($13.99/unit) |
| Hydrocortisone 1% Cream 28.35gm Tube | #1 for $16.99 | ($16.99/unit) |
| Hydrocortisone 2.5% Cream | #30 for $14.99 | ($0.50/unit) |
| Hydrocortisone 2.5% Ointment | # for $14.99 | |
| Hydrocortisone 1% Lotion 118ml Bottle | #1 for $13.99 | ($13.99/unit) |
| Hydrocortisone 20mg Tablets | #30 for $39.99 | ($1.33/unit) |
| Hydrocortisone 100mg/60ml Enema 60ml Bottle | #1 for $14.99 | ($14.99/unit) |
| Hydrocortisone 2.5% Lotion 59gm Bottle | #1 for $39.99 | ($39.99/unit) |
| Hydrocortisone 5mg Tablets | #50 for $23.99 | ($0.48/unit) |
| Hydrocortisone 10mg Tablets | #100 for $59.99 | ($0.60/unit) |
| Hydrocortisone Acetate (on 2/9/2012 at DrugStore.com) | ||
| Hydrocortisone Acetate 12 25mg Suppository Box | #1 for $15.00 | ($15.00/unit) |
| Hydrocortisone Acetate 1-1% Ointment 30gm Tube | #1 for $12.99 | ($12.99/unit) |
| Lidocaine-Hydrocortisone Ace (on 2/9/2012 at DrugStore.com) | ||
| Lidocaine-Hydrocortisone Ace 3-0.5% Kit Box | #1 for $25.99 | ($25.99/unit) |
| Lidocaine-Hydrocortisone Ace 3-0.5% Lotion 177ml Bottle | #1 for $195.99 | ($195.99/unit) |
| Hydrocortisone Ace-Pramoxine (on 2/9/2012 at DrugStore.com) | ||
| Hydrocortisone Ace-Pramoxine 2.5-1% Cream 28.35gm Tube | #1 for $49.99 | ($49.99/unit) |
| Hydrocortisone Ace-Pramoxine 1-1% Cream 30gm Tube | #1 for $79.99 | ($79.99/unit) |
| Hydrocortisone Ace-Pramoxine 2.5-1% Cream 30gm Tube | #1 for $49.99 | ($49.99/unit) |
| Hydrocortisone Valerate (on 2/9/2012 at DrugStore.com) | ||
| Hydrocortisone Valerate 0.2% Cream 15gm Tube | #1 for $19.37 | ($19.37/unit) |
| Hydrocortisone Valerate 0.2% Cream 60gm Tube | #1 for $45.88 | ($45.88/unit) |
| Hydrocortisone Valerate 0.2% Cream 45gm Tube | #1 for $34.67 | ($34.67/unit) |
| Hydrocortisone Valerate 0.2% Ointment 15gm Tube | #1 for $50.99 | ($50.99/unit) |
| Hydrocortisone Valerate 0.2% Ointment 60gm Tube | #1 for $119.98 | ($119.98/unit) |
| Hydrocortisone Valerate 0.2% Ointment 45gm Tube | #1 for $99.99 | ($99.99/unit) |
| Hydrocortisone Butyrate (on 2/9/2012 at DrugStore.com) | ||
| Hydrocortisone Butyrate 0.1% Solution 60ml Bottle | #1 for $27.99 | ($27.99/unit) |
| Hydrocortisone Butyrate 0.1% Cream 15gm Tube | #1 for $30.99 | ($30.99/unit) |
| Hydrocortisone Butyrate 0.1% Cream 45gm Tube | #1 for $53.99 | ($53.99/unit) |
| MethylPREDNISolone (Pak) (on 2/9/2012 at DrugStore.com) | ||
| MethylPREDNISolone (Pak) 21 4mg Tablets Disp Pack | #1 for $33.99 | ($33.99/unit) |
| MethylPREDNISolone (on 2/9/2012 at DrugStore.com) | ||
| MethylPREDNISolone 8mg Tablets | #25 for $51.99 | ($2.08/unit) |
| MethylPREDNISolone 16mg Tablets | #50 for $147.00 | ($2.94/unit) |
| Sulfacetamide-Prednisolone (on 2/9/2012 at DrugStore.com) | ||
| Sulfacetamide-Prednisolone 10-0.23% Solution 5ml Bottle | #1 for $25.99 | ($25.99/unit) |
| Sulfacetamide-Prednisolone 10-0.23% Solution 10ml Bottle | #1 for $30.99 | ($30.99/unit) |
| PrednisoLONE Sodium Phosphate (on 2/9/2012 at DrugStore.com) | ||
| PrednisoLONE Sodium Phosphate 1% Solution 10ml Bottle | #1 for $72.99 | ($72.99/unit) |
| PrednisoLONE Acetate (on 2/9/2012 at DrugStore.com) | ||
| PrednisoLONE Acetate 1% Suspension 5ml Bottle | #1 for $19.99 | ($19.99/unit) |
| PrednisoLONE Acetate 1% Suspension 10ml Bottle | #1 for $25.99 | ($25.99/unit) |
| PrednisoLONE Acetate 1% Suspension 15ml Bottle | #1 for $33.99 | ($33.99/unit) |
| PredniSONE (on 2/9/2012 at DrugStore.com) | ||
| PredniSONE 50mg Tablets | #30 for $17.99 | ($0.60/unit) |
| PredniSONE 5mg/5ml Solution | #30 for $14.99 | ($0.50/unit) |
| PredniSONE 1mg Tablets | #90 for $23.99 | ($0.27/unit) |
| PredniSONE 2.5mg Tablets | #30 for $12.99 | ($0.43/unit) |
| PredniSONE 10mg Tablets | #30 for $11.99 | ($0.40/unit) |
| PredniSONE 5mg Tablets | #100 for $12.99 | ($0.13/unit) |
| PredniSONE 20mg Tablets | #30 for $11.99 | ($0.40/unit) |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Adrenal Cortex Hormones (C0001617) |
|
|---|---|
| Definition (NCI) | Any steroid hormone made in the adrenal cortex (the outer part of the adrenal gland). They are also made in the laboratory. Corticosteroids have many different effects in the body, and are used to treat many different conditions. They may be used as hormone replacement, to suppress the immune system, and to treat some side effects of cancer and its treatment. Corticosteroids are also used to treat certain lymphomas and lymphoid leukemias. |
| Definition (CSP) | any of the 21-carbon steroids elaborated by the adrenal cortex (excluding the sex hormones of adrenal origin) in response to adrenocorticotropic hormone (ACTH) released by the pituitary gland or to angiotensin II; called also adrenocorticoid, corticoid, adrenal cortical or adrenocortical steroid, and adrenocortical or cortical hormone. |
| Definition (NCI) | Hormones synthesized in the cortex of the adrenal gland and consist of two subclasses, glucocorticoids (carbohydrate regulation) and mineralocorticoids (electrolyte regulation). |
| Concepts | Steroid (T110) , Pharmacologic Substance (T121) , Hormone (T125) |
| MSH | D000305 |
| SnomedCT | 332333008, 320476006, 79440004, 21568003 |
| English | Corticoid, Adrenal Cortex Hormones, Corticoids, Corticosteroids, Hormones, Adrenal Cortex, Adrenal cortical hormone, NOS, Corticoid preparation, NOS, Corticosteroids [resp], Corticosteroids [skin], Corticosteroids [skin] (product), Corticosteroids [respiratory use] (product), Corticosteroids [respiratory use], adrenal cortex hormone, corticosteroids, adrenal cortex hormones, corticoids, Corticosteroid [EPC], Adrenal Cortex Hormones [Chemical/Ingredient], Corticosteroid, Adrenal cortex hormones, adrenal corticosteroids, adrenal cortical hormone, adrenal corticosteroid, adrenocorticosteroids, corticoid, Adrenal cortical hormone, Adrenocorticosteroids, Corticoid preparation (product), Corticoid preparation, Adrenal cortical hormone (substance), corticosteroid, Corticoid preparation (substance), Corticosteroids [respiratory use] (substance), Corticosteroids [skin] (substance), Adrenal Cortex Steroids, Therapeutic Corticosteroid |
| Swedish | Binjurebarkshormoner |
| Spanish | corticosteroide (uso dermatológico), corticosteroide (uso dermatológico) (producto), corticosteroide [uso respiratorio] (producto), corticosteroide [uso respiratorio], corticoides (producto), preparado con corticoides (producto), corticoides, preparado con corticoides, Corticoesteroides, Corticosteroides, adrenocorticoesteroide, corticosteroides (piel) (producto), corticosteroides (piel), corticosteroides [uso respiratorio] (producto), corticosteroides [uso respiratorio], hormona de la corteza suprarrenal, hormona suprarrenal cortical (sustancia), hormona suprarrenal cortical, preparado de corticoides (producto), preparado de corticoides (sustancia), preparado de corticoides, Corticoides, Hormonas de la Corteza Suprarrenal |
| Czech | hormony kůry nadledvin, kortikosteroidy, kortikoidy |
| Finnish | Lisämunuaiskuoren hormonit |
| French | Hormones cortico-surrénaliennes, Corticoïdes, Corticostéroïdes, Hormones corticosurrénaliennes |
| Italian | Corticoidi, Corticosteroidi, Ormoni corticosurrenali |
| Russian | NADPOCHECHNIKOV KORY GORMONY, KORTIKOSTEROIDY, KORTIKOIDY, КОРТИКОИДЫ, КОРТИКОСТЕРОИДЫ, НАДПОЧЕЧНИКОВ КОРЫ ГОРМОНЫ |
| Croatian | KORTIKOSTEROIDI |
| Portuguese | Corticoesteróides, Corticóides, Corticosteróides, Hormônios do Córtex Supra-Renal |
| Polish | Hormony kory nadnerczy, Kortykoidy, Kortykosteroidy |
| Japanese | コルチコイド, 副腎皮質ホルモン, コルチコステロイド, ステロイドホルモン-副腎皮質, 副腎皮質ステロイド |
| German | Corticoide, Corticosteroide, Nebennierenrindenhormone |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Betamethasone (C0005308) |
|
|---|---|
| Definition (MSH) | A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724) |
| Definition (NCI) | A synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory activities. Betamethasone binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions. |
| Definition (PDQ) | A synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory activities. Betamethasone binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39273&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39273&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C303" NCI Thesaurus) |
| Concepts | Steroid (T110) , Pharmacologic Substance (T121) , Hormone (T125) |
| MSH | D001623 |
| SnomedCT | 116571008, 29896003 |
| English | Betadexamethasone, Betamethasone, Flubenisolone, Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-, betamethasone, betamethasone (medication), Betamethasone [Chemical/Ingredient], Betamethasone preparation, Flubenisolone preparation, Betamethasone (substance), Betamethasone preparation (product), Betamethasone preparation (substance), BETAMETHASONE |
| Swedish | Betametason |
| Czech | betamethason |
| Finnish | Beetametasoni |
| Italian | Betadesametasone, Flubenisolone, Betametasone |
| Russian | BETADEKSAMETAZON, BETAMETAZON, FLUBENIZOLON, БЕТАДЕКСАМЕТАЗОН, БЕТАМЕТАЗОН, ФЛУБЕНИЗОЛОН |
| Spanish | preparado de betametasona (producto), betametasona (producto), preparado de flubenisolona, preparado de betametasona, betametasona (sustancia), betametasona, preparado de betametasona (sustancia), Betadexametasona, Betametasona, Flubenisolona |
| Polish | Flubenisolonum, Betametazon |
| Japanese | フルベニソロン, ベタメタゾン, ベタデキサメタゾン |
| French | Bétaméthasone |
| German | Betadexamethason, Betamethason, Flubenisolon |
| Portuguese | Betadexametasona, Betametasona, Flubenisolona |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Cortisone (C0010137) |
|
|---|---|
| Definition (NCI) | A corticosteroid with potent glucocorticoid activity. Therapeutic cortisone is the inactive precursor molecule of the active hormone cortisol, which is the hydroxylation product of cortisone by 11-beta-steroid dehydrogenase. Cortisol increases blood pressure and blood sugar levels, and suppresses the immune system, therefore cortisone is used to treat allergies or inflammation. |
| Definition (MSH) | A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726) |
| Definition (CSP) | naturally occurring glucocorticoid used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent; cortisone itself is inactive and is converted in the liver to the active metabolite cortisol. |
| Definition (NCI) | A natural steroid hormone produced in the adrenal gland. It can also be made in the laboratory. Cortisone reduces swelling and can suppress immune responses. |
| Definition (NCI) | A steroid hormone synthesized and secreted by the adrenal gland and necessary for life. It is involved with maintaining cardiovascular function, blood glucose balance, regulating the inflammatory response and metabolism of proteins, carbohydrates, and fat. |
| Concepts | Steroid (T110) , Pharmacologic Substance (T121) , Hormone (T125) |
| MSH | D003348 |
| SnomedCT | 32498003, 111150008 |
| English | cortisone, Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-, 17,21-Dihydroxypregn-4-ene-3,11,20-trione, Cortisone, Cortisone [Chemical/Ingredient], cortisones, Compound E, Cortisone preparation, Cortisone (substance), Cortisone preparation (product), Cortisone product, CORT, Cortisone preparation (substance), Therapeutic Cortisone, CORTISONE |
| Swedish | Kortison |
| Czech | kortison |
| Finnish | Kortisoni |
| Russian | KORTIZON, КОРТИЗОН |
| Japanese | コルチゾン, 11-デヒドロ-17-ヒドロキシコルチコステロン |
| Spanish | preparado con cortisona (producto), cortisona (producto), preparado con cortisona, cortisona (sustancia), cortisona, preparado de cortisona (producto), preparado de cortisona (sustancia), preparado de cortisona, Cortisona |
| Croatian | KORTIZON |
| Polish | Kortyzon |
| French | Cortisone |
| German | Cortison |
| Italian | Cortisone |
| Portuguese | Cortisona |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Dexamethasone (C0011777) |
|
|---|---|
| Definition (CHV) | a kind of steroid drug |
| Definition (CHV) | a kind of steroid drug |
| Definition (CSP) | anti-inflammatory 9-fluoro-glucocorticoid. |
| Definition (MSH) | An anti-inflammatory 9-fluoro-glucocorticoid. |
| Definition (PSY) | A synthetic analogue of cortisol. |
| Definition (NCI) | A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04) |
| Definition (NCI) | A synthetic steroid (similar to steroid hormones produced naturally in the adrenal gland). Dexamethasone is used to treat leukemia and lymphoma and may be used to treat some of the problems caused by other cancers and their treatment. |
| Definition (PDQ) | A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39789&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39789&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C422" NCI Thesaurus) |
| Concepts | Steroid (T110) , Pharmacologic Substance (T121) |
| MSH | D003907 |
| SnomedCT | 325354000, 372584003, 7561000, 116568000 |
| English | Dexamethasone, Hexadecadrol, Methylfluorprednisolone, Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-, 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone, 9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione, 9Alpha-fluoro-16alpha-methylprednisolone, 9alpha-Fluoro-16alpha- methylprednisolone, Fluoro-9alpha Methyl-16alpha Prednisolone, (11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione, 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone, 16Alpha-methyl-9alpha-fluoroprednisolone, dexamethasone, Dexamethasonum, Desamethasone, Dexamethasone [endocrine use], DEXAMETHASONE, Dexamethasone [endocrine use] (product), dexamethasone (medication), Dexamethasone [Chemical/Ingredient], dexamethasone (DMX), Dexamethasone preparation, Dexamethasone (substance), Dexamethasone preparation (product), DXM, DM, Dexamethasone (product), Dexamethasone [endocrine use] (substance), Dexamethasone preparation (substance) |
| Swedish | Dexametason |
| Czech | dexamethason |
| Finnish | Deksametasoni |
| Russian | DEKSAMETAZON, GEKSADEKADROL, ГЕКСАДЕКАДРОЛ, ДЕКСАМЕТАЗОН |
| Spanish | dexametasona (uso endocrino) (producto), dexametasona (uso endocrino), preparado con dexametasona (producto), dexametasona (producto), preparado con dexametasona, dexametasona (sustancia), dexametasona, preparado de dexametasona (producto), preparado de dexametasona (sustancia), preparado de dexametasona, Dexametasona, Hexadecadrol |
| Japanese | コルソン, デキサA, デキサメサゾン, ダブM, デカドロン, ビスオDS, ミタゾーン, オイラゾンD, デカドロンN, デキサ･チョーセイ, デキサ･ママレット, デキサメ, ヘキサデカドロール, デルゾン, サンテゾーン, デキサルチン, フルメプレドニゾロン, マキシデックス, デキサメタゾン, エースミン |
| Italian | Metil-fluoro-prednisolone, Esadecadrol, Desametasone |
| Croatian | DEKSAMETAZON |
| Polish | Deksametazon |
| French | Dexaméthasone |
| German | Dexamethason, Hexadecadrol |
| Portuguese | Dexametasona, Hexadecadrol |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Hydrocortisone (C0020268) |
|
|---|---|
| Definition (NCI) | A hormone made by the adrenal cortex (the outer layer of the adrenal gland). It helps the body use glucose (a sugar), protein, and fats. Cortisol made in the laboratory is called hydrocortisone. It is used to treat many conditions, including inflammation, allergies, and some cancers. Cortisol is a type of glucocorticoid hormone. |
| Definition (MSH) | The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. |
| Definition (CSP) | main glucocorticoid secreted by the adrenal cortex; its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. |
| Definition (NCI) | A synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. (NCI04) |
| Definition (NCI) | A drug used to relieve the symptoms of certain hormone shortages and to suppress an immune response. |
| Definition (PDQ) | A synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39274&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39274&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C555" NCI Thesaurus) |
| Concepts | Steroid (T110) , Pharmacologic Substance (T121) , Hormone (T125) |
| MSH | D006854 |
| SnomedCT | 396458002, 56423005, 16602005 |
| English | Compound F, Cortisol, Hydrocortisone, Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-, Dihydrocortisone, (11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione, hydrocortisone, Cortisol (substance), Domolene, Therapeutic Hydrocortisone, hydrocortisone (medication), 17-hydroxycorticosterone, HYDROCORTISONE, Hydrocortisone [Chemical/Ingredient], cortisols, hydrocortisones, Compound F preparation, Cortisol preparation, Cortisol product, HC - Hydrocortisone, Hydrocortisone preparation, Hydrocortisone product, Hydrocortisone (substance), Hydrocortisone preparation (product), cortisol, HC, Hydrocortisone preparation (substance) |
| Swedish | Hydrokortison |
| Spanish | cortisol, cortisol (sustancia), preparado con hidrocortisona (producto), hidrocortisona (producto), preparado con hidrocortisona, hidrocortisona (sustancia), hidrocortisona, preparado de hidrocortisona (producto), preparado de hidrocortisona (sustancia), preparado de hidrocortisona, Cortisol, Hidrocortisona |
| Czech | hydrokortison, kortisol, kortizol, hydrokortizon |
| Finnish | Kortisoli |
| Russian | KORTIZOL, GIDROKORTIZON, ГИДРОКОРТИЗОН, КОРТИЗОЛ |
| Japanese | コルチソール, ヒドロコルチゾン, コルチソル, 17-ヒドロキシコルチコステロン, ハイドロコルチゾン, コートリル, コルチゾール |
| Italian | Cortisolo, Idrocortisone |
| Croatian | HIDROKORTIZON |
| Polish | Hydrokortyzon, Kortyzol |
| French | Cortisol, Hydrocortisone |
| German | Cortisol, Hydrocortison, Kortisol |
| Portuguese | Cortisol, Hidrocortisona |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Methylprednisolone (C0025815) |
|
|---|---|
| Definition (CHV) | a kind of steroidal anti-inflammatory drugs |
| Definition (MSH) | A PREDNISOLONE derivative with similar anti-inflammatory action. |
| Definition (CSP) | synthetic glucocorticoid derived from progesterone, used in replacement therapy for adrenal insufficiency and as an anti-inflammatory and immunosuppressant. |
| Definition (NCI) | A corticosteroid hormone replacement. |
| Definition (NCI) | A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. |
| Definition (PDQ) | A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41528&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41528&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C647" NCI Thesaurus) |
| Concepts | Steroid (T110) , Pharmacologic Substance (T121) , Hormone (T125) |
| MSH | D008775 |
| SnomedCT | 325387001, 116593003, 27242001 |
| English | 6 Methylprednisolone, 6-Methylprednisolone, Methylprednisolone, Metipred, Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-6-methyl-, (6alpha,11beta)-, Methylprednisolone [endoc], 6Alpha-Methylprednisolone, (6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione, methylprednisolone, Methylprednisolonum, Methylprednisolone [endocrine use], Methylprednisolone [endocrine use] (product), methylprednisolone (medication), METHYLPREDNISOLONE, Methylprednisolone [Chemical/Ingredient], methylPREDNISolone, 6-alpha-Methylprednisolone preparation, Methylprednisolone preparation, Methylprednisolone (substance), Methylprednisolone preparation (product), MePRDL, Methylprednisolone [endocrine use] (substance), Methylprednisolone preparation (substance), MethylPREDNISolone |
| Swedish | Metylprednisolon |
| Czech | methylprednisolon |
| Finnish | Metyyliprednisoloni |
| Russian | METILPREDNIZOLON, METIPRED, URBAZON, МЕТИЛПРЕДНИЗОЛОН, МЕТИПРЕД, УРБАЗОН |
| Spanish | metilprednisolona (uso endocrino) (producto), metilprednisolona (uso endocrino), preparado con 6-alfa-metilprednisolona, preparado con metilprednisolona (producto), metilprednisolona (producto), preparado con metilprednisolona, metilprednisolona (sustancia), metilprednisolona, preparado de 6-alfa-metilprednisolona, preparado de metilprednisolona (producto), preparado de metilprednisolona (sustancia), preparado de metilprednisolona, Metilprednisolona |
| Japanese | メドロール, メチルプレドニゾロン, メチルプレドニソロン, ウルバソン |
| French | 6-Méthylprednisolone, Méthylprednisolone |
| Croatian | METILPREDNISOLON |
| Polish | Metyloprednizolon |
| German | Methylprednisolon |
| Italian | Metilprednisolone |
| Portuguese | Metilprednisolona |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
prednisolone (C0032950) |
|
|---|---|
| Definition (NCI) | A drug that lessens inflammation and suppresses the body's immune response. It may also kill cancer cells. Prednisolone is used to treat disorders in many organ systems and to treat the symptoms of several types of leukemia and lymphoma. It is also being studied in the treatment of other types of cancer. Prednisolone is a type of therapeutic glucocorticoid. |
| Definition (MSH) | A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. |
| Definition (CSP) | synthetic glucocorticoid with the general properties of the corticosteroids. |
| Definition (NCI) | A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04) |
| Definition (PDQ) | A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43296&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43296&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C769" NCI Thesaurus) |
| Concepts | Steroid (T110) , Pharmacologic Substance (T121) |
| MSH | D011239 |
| SnomedCT | 325425005, 317418003, 116601002, 52388000 |
| English | Prednisolone, Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-, Prednisolone [for preparations see rectal prednisolone], Prednisolone [see rectal pred], .delta.1-Hydrocortisone, 1,2-Dehydrohydrocortisone, (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione, Metacortandralone, Delta(1)Hydrocortisone, Delta-F, Delta1-dehydro-hydrocortisone, Prednisolonum, Prednisolone [endocrine use], Prednisolone [for preparations see rectal prednisolone] (product), Prednisolone [endocrine use] (product), prednisolone (medication), PREDNISOLONE, Prednisolone [Chemical/Ingredient], prednisoLONE, Deltahydrocortisone, Deltahydrocortisone preparation, Metacortandralone preparation, Prednisolone preparation, Prednisolone product, Prednisolone (substance), Prednisolone preparation (product), PRDL, Prednisolone [endocrine use] (substance), Prednisolone [for preparations see rectal prednisolone] (substance), Prednisolone preparation (substance), prednisolone, PrednisoLONE |
| Swedish | Prednisolon |
| Czech | prednisolon, depersolon |
| Finnish | Prednisoloni |
| Russian | DEPERZOLON, PREDNIZOLON, ДЕПЕРЗОЛОН, ПРЕДНИЗОЛОН |
| Spanish | prednisolona (para preparaciones ver prednisolona rectal) (producto), prednisolona (uso endocrino) (producto), prednisolona (para preparaciones ver prednisolona rectal), prednisolona (uso endocrino), preparado con metacortandralona, preparado con prednisolona (producto), prednisolona (producto), preparado con deltahidrocortisona, preparado con prednisolona, prednisolona (sustancia), prednisolona, preparado de deltahidrocortisona, preparado de metacortandralona, preparado de prednisolona (producto), preparado de prednisolona (sustancia), preparado de prednisolona, Prednisolona |
| Japanese | プレドニソロン, デルポPD, ドニソロン, プレドニン, シエリゾロン, プレドニゾロン |
| Croatian | PREDNIZOLON |
| Polish | Encortolon, Prednizolon |
| French | Prednisolone |
| German | Prednisolon |
| Italian | Prednisolone |
| Portuguese | Prednisolona |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |