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IbuprofenAka: Motrin, Advil, Nuprin
- Indications
- Fever
- Analgesia
- Mechanism: NSAID - Propionic Acid
- Strong Analgesic action
- Moderate anti-inflammatory action (Dose >= 600 mg)
- Supplied
- Suspension: 100 mg/5ml
- Chewables: 50 mg, 100 mg
- Oral drops: 40 mg/ml
- Tablets: 100 mg, 200 mg, 300 mg, 400 mg, 600 mg, 800 mg
- Dosing: Children older than age 6 months
- Dose: 5-10 mg/kg PO every 6 to 8 hours
- Dosing: Adult
- Dose: 200 to 800 mg PO tid to qid
- Maximum: 2400 mg/day
- Contraindications
- Avoid in age under 6 months old
- Adverse Effects
Ibuprofen (C0020740) | |
|---|---|
| Definition (MSH) | A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis. |
| Definition (CSP) | nonsteroidal analgesic, antipyretic and anti-inflammatory agent that is a propionic acid derivative. |
| Definition (PDQ) | A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40475&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40475&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C561" NCI Thesaurus) |
| Definition (NCI) | A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05) |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D007052 |
| English | Ibuprofen, IBUPROFEN PREPARATION, Ibuprofen product, p-Isobutylhydratropic acid, Propionic acid-ibuprofen |
| Spanish | acido p-isobutilhidratropico, ibuprofeno |
| Parent Concepts | saturated carboxylic acid (C0682939), Analgesics (C0002771), Anti-Inflammatory Agents, Non-Steroidal (C0003211), Benzoates (C0005058), Phenylpropionates (C0031497), Cyclooxygenase Inhibitors (C0085387), Antipyretics (C0003419), [MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC (C0973575), [CN104] NONSTEROIDAL ANTI-INFLAMMATORY ANALGESICS (C0991599), Ibuprofen (C0020740), Propionic acid derivative anti-inflammatory agent (C1626403), Duplicate concept (C1274013), Nonsteroidal Anti-inflammatory Drugs, Nonspecific (C1579332) |
| Sources | AOD, CSP, LNC, MSH, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF Derived from the NIH UMLS (Unified Medical Language System) |
Advil (C0593507) | |
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| English | Advil |
| Sources | MTH, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
Motrin (C0699203) | |
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D007052 |
| English | Motrin |
| Sources | MSH, NCI, PDQ, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
Nuprin (C0699205) | |
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D007052 |
| English | Nuprin |
| Sources | MSH, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
