Pharmacology Book

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Ibuprofen

Aka: Ibuprofen, Motrin, Advil, Nuprin
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  1. Indications
    1. Fever
    2. Analgesia
  2. Mechanism: NSAID - Propionic Acid
    1. Strong Analgesic action
    2. Moderate anti-inflammatory action (Dose >= 600 mg)
  3. Supplied
    1. Suspension: 100 mg/5ml
    2. Chewables: 50 mg, 100 mg
    3. Oral drops: 40 mg/ml
    4. Tablets: 100 mg, 200 mg, 300 mg, 400 mg, 600 mg, 800 mg
  4. Dosing: Children older than age 6 months
    1. Dose: 5-10 mg/kg PO every 6 to 8 hours
  5. Dosing: Adult
    1. Dose: 200 to 800 mg PO tid to qid
    2. Maximum: 2400 mg/day
  6. Contraindications
    1. Avoid in age under 6 months old
  7. Adverse Effects
    1. See NSAID Gastrointestinal Adverse Effects
    2. See NSAID Renal Adverse Effects
Medication Costs
IBUPROFEN (on 2/10/2012 at Target.com)
IBUPROFEN 100 MG/5 ML* Suspension #30 for $4.00 ($0.13/unit)
IBUPROFEN 400 MG Tablet #30 for $4.00 ($0.13/unit)
IBUPROFEN (on 2/10/2012 at Target.com)
IBUPROFEN 600 MG Tablet #30 for $4.00 ($0.13/unit)
IBUPROFEN 800 MG Tablet #30 for $4.00 ($0.13/unit)
IBUPROFEN 100 MG/5 ML* Suspension #30 for $4.00 ($0.13/unit)
IBUPROFEN 400 MG Tablet #30 for $4.00 ($0.13/unit)
Oxycodone-Ibuprofen (on 2/9/2012 at DrugStore.com)
Oxycodone-Ibuprofen 5-400mg Tablets #20 for $33.33 ($1.67/unit)
Ibuprofen (on 2/9/2012 at DrugStore.com)
Ibuprofen 500 200mg Tablets Bottle #1 for $16.99 ($16.99/unit)
Ibuprofen 400mg Tablets #30 for $11.99 ($0.40/unit)
Ibuprofen 600mg Tablets #90 for $14.99 ($0.17/unit)
Ibuprofen 800mg Tablets #30 for $12.99 ($0.43/unit)
Hydrocodone-Ibuprofen (on 2/9/2012 at DrugStore.com)
Hydrocodone-Ibuprofen 7.5-200mg Tablets #30 for $33.99 ($1.13/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ibuprofen (C0020740)

Definition (CHV) a chemical substance
Definition (CHV) a chemical substance
Definition (NCI) A drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID).
Definition (MSH) A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.
Definition (CSP) nonsteroidal analgesic, antipyretic and anti-inflammatory agent that is a propionic acid derivative.
Definition (NCI) A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05)
Definition (PDQ) A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40475&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40475&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C561" NCI Thesaurus)
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D007052
SnomedCT 322295006, 329651005, 329955004, 38268001, 387207008, 363606004
English Ibuprofen, alpha-Methyl-4-(2-methylpropyl)benzeneacetic Acid, Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-, Ibuprofen [cns analgesic], Ibuprofen [cns analgesic] [see j28..], Ibuprofen [musc-skel], Benzeneacetic Acid, Alpha-methyl-4-(2-methylpropyl)-, (.+ -.)-p-Isobutylhydratropic acid, p-Isobutylhydratropic Acid, ibuprofen, Ibuprofen [musculoskeletal use], Ibuprofen product, Ibuprofen [cns analgesic] [see j28..] (product), Ibuprofen [musculoskeletal use 2] (product), Ibuprofen [musculoskeletal use] (product), ibuprofen (OTC), ibuprofen (medication), Ibuprofen PMR, Ibuprofen [musc-skel use 2], Ibuprofen [musculoskeletal use 2], non-prescription ibuprofen, non-prescription ibuprofen (medication), IBUPROFEN, Ibuprofen [Chemical/Ingredient], ibuprofen products, Propionic acid-ibuprofen, p-Isobutylhydratropic acid, Ibuprofen (product), Ibuprofen (substance), Ibuprofen [cns analgesic] [see j28..] (substance), Ibuprofen [musculoskeletal use 2] (substance), Ibuprofen [musculoskeletal use] (substance), Ibuprofen product (substance)
Swedish Ibuprofen
Czech ibuprofen
Spanish Ibuprofen product, Ibuprofen product (substance), ibuprofeno [uso musculoesquelético] (producto), ibuprofeno [uso musculoesquelético 2], ibuprofeno [uso musculoesquelético], ibuprofeno [uso musculoesquelético 2] (producto), ibuprofeno [analgésico de acción central] [véase j28..], ibuprofeno [analgésico de acción central] [véase j28..] (producto), ibuprofeno (producto), ibuprofeno (sustancia), ibuprofeno, ácido p-isobutilhidratrópico, Ibuprofeno
Finnish Ibuprofeeni
Russian IBUPROFEN, ИБУПРОФЕН
Japanese イブプロフェン
Polish Ibuprofen, Brufen
French Ibuprofène
German Ibuprofen
Italian Ibuprofene
Portuguese Ibuprofeno
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Advil (C0593507)

Definition (CHV) brand name of a pain killer drug
Definition (CHV) brand name of a pain killer drug
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
English Advil, advil [brand name], advil
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Motrin (C0699203)

Definition (CHV) brand name of ibuprofen
Definition (CHV) brand name of ibuprofen
Definition (CHV) brand name of ibuprofen
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D007052
English Motrin IB, motrin [brand name], motrin ib, motrin, Motrin
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Nuprin (C0699205)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D007052
English nuprin, Nuprin
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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