Otolaryngology Book

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Intranasal SteroidAka: Corticosteroid Intranasal, Nasacort, Rhinocort, Nasarel, Beconase, Vancenase, Flonase

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  1. Efficacy of Intranasal Steroids
    1. Significantly reduced symptoms
      1. Reduced nasal obstruction
      2. Reduced Rhinorrhea, sneezing, and nasal itching
      3. By comparison, Seldane was same as Placebo
    2. Reference
      1. Bronsky (1996) J Allergy Clin Immunol 97:915
  2. Safety
    1. Appears safe in children as young as age 2 years
      1. No hypothalamic-pituitary-adrenal axis suppression
      2. Galant (2003) Pediatrics 112:96
  3. Adverse Effects
    1. Epistaxis
      1. Reduced by spraying away from septum
      2. Use left hand when spraying right nostril
      3. Use right hand when spraying left nostril
      4. (2004) Prescribers Letter 11(1):2
  4. General
    1. Aqueous Preparations: Better for dry nose, winter
      1. Moisturizing: Nasarel (Flunisolide)
      2. Moisture neutral: Nasocort AQ and Rhinocort AQ
      3. Drying agents (Alcohol): most AQ agents
    2. Non-Aqueous: Better for "wet", watery nose
  5. Preparations
    1. Flunisolide (Nasalide)
      1. Dose: 2 puffs in nose bid
      2. Relative potency: 3
    2. Fluticasone (Flonase)
      1. Dose: 2 puffs qd x1wk, then 1 puff qd
      2. Relative potency: 10
    3. Triamcinolone acetonide (Nasacort)
      1. Dose: 2 puffs qd for 1 week, then 1 puff per day
      2. Relative potency: 1
    4. Beclomethasone dipropionate (Beconase, Vancenase)
      1. Relative potency: 5
      2. Dose: 2 puffs bid (2 puffs qd for double strength)
    5. Budesonide (Rhinocort)
      1. Dose: 4 puffs qd for 1 week, then 2 puffs qd
      2. Relative potency: 10

Flonase (C0286677)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC065382
EnglishFlonase
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Beconase (C0591154)

ConceptsSteroid (T110) , Pharmacologic Substance (T121)
MSHC107432, D001507
EnglishA & H Brand of Beclomethasone Dipropionate, Allen & Hanburys Brand of Beclomethasone Dipropionate, Becloforte, becodisk, Becodisks, Beconase, Becotide, Glaxo Wellcome Brand of Beclomethasone Dipropionate, GlaxoSmithKline Brand 1 of Beclomethasone Dipropionate, Propaderm, Sanasthmyl, Shire Brand of Beclomethasone Dipropionate
SourcesMSH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Nasacort (C0594040)

ConceptsSteroid (T110) , Pharmacologic Substance (T121)
EnglishNasacort
SourcesNCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Rhinocort (C0678163)

ConceptsSteroid (T110) , Pharmacologic Substance (T121)
MSHD019819
EnglishRhinocort
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Vancenase (C0699072)

ConceptsSteroid (T110) , Pharmacologic Substance (T121)
MSHD001507
EnglishSchering Brand 1 of Beclomethasone Dipropionate, Vancenase
SourcesMSH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Nasarel (C0721979)

ConceptsSteroid (T110) , Pharmacologic Substance (T121)
MSHC007734
EnglishElan Brand 2 of Flunisolide, Nasarel
SourcesMSH, MTH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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