Neurology Book

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Myopathy

Aka: Myopathy, Myositis
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  1. See Also
    1. Myopathy Causes
    2. Acute Motor Weakness Causes
    3. Muscular Dystrophy
  2. Findings
    1. Suggestive of Myopathy
      1. Gradual onset of symmetric weakness
      2. Proximal weakness
        1. Difficulty combing hair
        2. Difficulty walking up stairs
      3. Neck Flexion weaker than neck extension
      4. Deep Tendon Reflexes preserved
    2. Suggestive of alternative diagnosis (i.e. Neuropathy)
      1. Sudden onset of asymmetric weakness
      2. Paresthesias in extremities
      3. Bowel dysfunction (e.g. Stool Incontinence)
      4. Bladder dysfunction (e.g. Urinary Incontinence)
      5. Distal weakness suggests Neuropathy
        1. Except in Guillain-Barre, Myotonic Dystrophy
      6. Deep Tendon Reflexes lost
  3. History: Direct to specific Myopathy
    1. Family History of Myopathy: Muscular Dystrophy
    2. Difficult swallowing: Polymyositis
    3. Weakness varies and includes eyes: Myasthenia Gravis
    4. Age of onset
      1. Age <30: Muscular Dystrophy
  4. Labs
    1. Creatine Phosphokinase (CPK) increased
    2. Aspartate Aminotransferase (AST) may be increased
    3. Aldolase may be increased
    4. Lactate Dehydrogenase (LDH) may be increased
  5. Diagnostics
    1. Electromyogram (EMG)
    2. Nerve Conduction Studies (NCS)
    3. Muscle biopsy
  6. Causes
    1. See Myopathy Causes
    2. See Medication Causes of Myositis
    3. See Muscular Dystrophy
    4. See Acute Motor Weakness Causes
      1. Critical to rule-out emergent causes
    5. List of some treatable myopathies
      1. Thyroid Myopathy (Hypothyroidism, Hyperthyroidism)
      2. Steroid Myopathy
      3. Polymyositis
      4. Alcoholic Myopathy
      5. Periodic paralysis
      6. Polymyalgia Rheumatica
      7. Myasthenia Gravis
      8. Eaton-Lambert Syndrome

Myositis (C0027121)

Definition (MSH) Inflammation of a muscle or muscle tissue.
Definition (NCI) An inflammatory process affecting the skeletal muscles. Causes include infections, injuries, and autoimmune disorders.
Definition (NCI) A disorder characterized by inflammation involving the skeletal muscles.
Definition (SNOMEDCT) Inflammation of skeletal muscle, not including inflammation of cardiac muscle
Definition (MEDLINEPLUS)

Myositis is inflammation of your skeletal muscles, which are also called the voluntary muscles. These are the muscles you consciously control that help you move your body. An injury, infection or autoimmune disease can cause myositis.

The diseases dermatomyositis and polymyositis both involve myositis. Polymyositis causes muscle weakness, usually in the muscles closest to the trunk of your body. Dermatomyositis causes muscle weakness, plus a skin rash. Both diseases are usually treated with prednisone, a steroid medicine, and sometimes other medicines.
Definition (CSP) inflammation of skeletal muscle.
Concepts Disease or Syndrome (T047)
MSH D009220
ICD10 M60, M60.9, G72.49
SnomedCT 203110007, 26889001, 128496001, 268108002
English Myositides, MYOSITIS, Myositis, NOS, Myositis unspecified, Myositis, unspecified, INFLAMM MUSCLE DIS, MUSCLE DIS INFLAMM, INFLAMM MYOPATHY, MYOPATHY INFLAMM, inflammatory myopathy, inflammatory myopathy (diagnosis), MYOSITIS INFLAMMATORY, Inflammatory Muscle Disease, Inflammatory Muscle Diseases, Muscle Disease, Inflammatory, Muscle Diseases, Inflammatory, Inflammatory Myopathies, Inflammatory Myopathy, Myopathies, Inflammatory, Myopathy, Inflammatory, Myositis unspecified (disorder), Inflammatory myopathy NOS, Myositis [Disease/Finding], Myositis, Unspecified myositis, inflammation of the skeletal muscle, inflammatory muscle disease, inflammatory muscle diseases, myositis nos, Inflammation;muscle(s), muscle inflammation, inflammatory myopathies, Inflammatory disorder of muscle (disorder), Inflammatory disorder of muscle, Inflammatory myopathy, Myositis (disorder), myositis, disease (or disorder); muscle, inflammatory, inflammation; muscle, inflammatory; myopathy, muscle; disease, inflammatory, muscle; inflammation, myopathy; inflammatory, Myositis NOS, Muscle inflammation, inflammation of the muscle(s)
French MYOSITE, Inflammation musculaire, Myosite, Maladies inflammatoires des muscles, Myopathie inflammatoire
Portuguese MIOSITE, Inflamação muscular, Miosite, Miopatia Inflamatória
Spanish MIOSITIS, Inflamación muscular, Myositis NOS, miopatía inflamatoria (trastorno), miopatía inflamatoria, miositis (trastorno), miositis, no especificada (trastorno), miositis, no especificada, miositis, trastorno muscular inflamatorio, Miositis, Miopatía Inflamatoria, Miopatia Inflamatoria
German MYOSITIS, Muskelentzuendung, Myositis, nicht naeher bezeichnet, Myositis, Entzündliche Myopathie, Muskelentzündung
Dutch spierontsteking, aandoening; spier, inflammatoir, inflammatoir; myopathie, myopathie; inflammatoir, ontsteking; spier, spier; aandoening, inflammatoir, spier; ontsteking, Myositis, niet gespecificeerd, myositis, Inflammatoire myopathie, Myositis
Italian Infiammazione muscolare, Miosite
Japanese 筋肉の炎症, ｷﾝｴﾝ, ｷﾝﾆｸﾉｴﾝｼｮｳ, 筋炎, 筋肉炎
Swedish Muskelinflammation
Czech myozitida, zánětlivé nemoci svalů, svaly - zánět, zánětlivá myopatie, Zánět svalu, Myozitida
Finnish Myosiitti
Russian MIOZIT, МИОЗИТ
Korean 근육염, 상세불명의 근육염
Croatian UPALA MIŠIĆA, MIOZITIS
Polish Zapalenie mięśni eozynofilowe, Zapalenie mięśni
Hungarian Myositis, Izomgyulladás
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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