II. Management: General

  1. Offer Reassurance
    1. Not a serious physical disease
    2. Not insanity
    3. Not a sign of weakness or failure
    4. Not childishness or overdependency
    5. Not life-threatening
  2. Encourage Acceptance of anxiety as a life-long problem
    1. Innate response with years of reinforcement
    2. Complete calm always is unrealistic goal
  3. Set Goals for Therapy
    1. Decrease level of anxiety and maintain at low level
    2. Modulate future symptom responses
    3. Increase functioning

III. Management: Lifestyle Modification

  1. Daily Physical Exercise (e.g. Walking, Tennis, Aerobics, Bicycling)
    1. Likely effective, although less than with Major Depression, and with inadequate evidence to date
    2. Jayakody (2014) Br J Sports Med 48(3): 187-96 [PubMed]
    3. Stonerock (2015) Ann Behav Med 49(4): 542-6 [PubMed]
  2. Improve sleep quality
    1. Establish good Sleep Hygiene
  3. Consider new hobbies
  4. Consider Pet Therapy
    1. Zawisa (2024) Am Fam Physician 110(4): 423 [PubMed]
  5. Avoid harmful intakes (See Anxiety Secondary Causes)
    1. Avoid Alcohol use
    2. Avoid Tobacco use
    3. Avoid Caffeine
    4. Avoid Substance Abuse

IV. Management: Psychotherapy

  1. Background
    1. Optimal effects are after 8 weeks of weekly sessions
    2. As effective as medication for the treatment of Generalized Anxiety Disorder and Panic Disorder
  2. Goals
    1. Increase self confidence
    2. Increase self control
    3. Promote emotional growth
  3. Specific areas of education
    1. Teach coping skills and Conflict Resolution
    2. Encourage patient to express themselves
  4. Practice goal directed behavior
    1. Redirect energy and creativity
    2. Identify a new source of fulfillment
  5. Cognitive Behavioral Therapy
    1. First-line directed, time limited intervention for mild to moderate anxiety
    2. May be delivered in individual or group therapy, typically 12-20 week course, followed by months of booster sessions
    3. Recognize how thoughts affect mood and behavior, and then modify thinking and behavior
      1. Systematic Desensitization with exposure therapy (most effective single measure)
      2. Recognize, Reexamine and replace anxious thoughts
      3. Behavioral interventions include social skill training, relaxation and exposure
    4. James (2020) Cochrane Database Syst Rev 11(11):CD013162 +PMID: 33196111 [PubMed]

V. Management: Mindfulness and relaxation

  1. See Relaxation Training
  2. Mindfulness-based Interventions (including stress reduction)
    1. Appears effective, but variable benefit in studies to date
      1. Goldberg (2018) Clin Psychol Rev 59:52-60 [PubMed]
      2. Khoury (2013) Clin Psychol Rev 33(6): 763-71 [PubMed]
    2. Non-inferior to SSRI therapy (Escitalopram) with sustained benefit at 6 months
      1. Hoge (2023) JAMA Psychiatry 80(1): 13-21 [PubMed]
  3. Progressive Muscle Relaxation
  4. Relaxation Training
    1. Meditation
    2. Yoga
      1. Likely offers benefit, but effects appear small, adjunctive
      2. Hoffman (2016) J Evid Based Med 9(3):116-24 [PubMed]
    3. Self-Hypnosis
    4. Tai Chi
      1. Effective in older adults with anxiety (symptom control with less relapse)
      2. Song (2014) J Physiol Pathophysiol Pharmacol 6(1): 55-60 [PubMed]
  5. Biofeedback
  6. Breathing retraining (arousal reduction)
    1. Take a deep breath
    2. Let breath out through pursed lips

VI. Management: Measures to Avoid

  1. Virtual Reality Exposure Therapy does not appear effective and should not be used as therapy for GAD
    1. Hungenberg (2021) Am Fam Physician 104(6): 638-40 [PubMed]
    2. Wechsler (2019) Front Psychol 10: 1758 +PMID: 31551840 [PubMed]

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