Coxsackie Virus B

Aka: Coxsackie Virus B, Coxsackievirus B, Coxsackie B Virus, Group B Coxsackie Virus

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II. Pathophysiology

  1. Coxsackie Viruses are Enteroviruses in the Picornaviridae family
    1. Picornaviridae are a family of non-enveloped (naked) RNA Viruses with an icosahedral capsid
    2. Picornaviridae are linear, Message Sense RNA Viruses (Positive Stranded, +ssRNA)
      1. Message sense RNA (+ssRNA) are identical to Messenger RNA (mRNA)
      2. Like mRNA, +ssRNA may be immediately translated by host ribosomes into Protein
  2. Enterovirus
    1. Enteroviruses infect small intestinal epithelial cells (peyer's patches) and lymphoid cells (Tonsils)
    2. Enteroviruses may also infect other tissue (e.g. Neurons) depending on the specific virus
    3. Transmission in pharyngeal secretions and via fecal-oral route

III. Findings: Presentations

  1. Viral Syndrome
    1. Fever, malaise and myalgias
    2. Gastrointestinal symptoms (e.g. Nausea, Vomiting, Diarrhea)
    3. Viral Exanthem may be present
  2. Cardiopulmonary syndromes
    1. Epidemic Pleurodynia (Devil's Grip, Bornholm Disease)
    2. Pericarditis
    3. Myocarditis
  3. Neurologic syndromes
    1. Aseptic Meningitis
    2. Encephalitis
  4. Gastrointestinal Syndromes
    1. Pancreatitis (with associated development of Type I Diabetes Mellitus)
    2. Hepatitis

IV. Resources

  1. Group B Coxsackie Virus (Stat Pearls)
    1. https://www.ncbi.nlm.nih.gov/books/NBK560783/
  2. Pozzetto (1999) Coxsackieviruses in Encyclopedia of Virology, p. 305-11
    1. https://pmc.ncbi.nlm.nih.gov/articles/PMC7173574/

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