II. Indications: Conditions

  1. Gram-Negative, Multi-drug resistant intraabdominal Infections and Urinary Tract Infections

III. Pharmacokinetics

  1. Half-Life Ceftazidime: 2.7 hours (similar for Avibactam)
  2. Ceftazidime is excreted in urine (80-90% unchanged, avibactam is 100% unchanged on excretion)
  3. Adjust dose in Renal Failure

IV. Indications: Bacterial Coverage

V. Preparations

  1. Ceftazidime (Fortaz)
    1. Adult: 1-2 grams IM or IV every 8 to 12 hours
    2. Child: 30-50 mg/kg IV every 8 hours
  2. Ceftazidime-Avibactam (Zavicefta)
    1. Addition of Beta-Lactamase inhibitor (Avibactam) circumvents Beta-Lactamase resistance
    2. Ceftazidime-Avibactam (2g-0.5g) 62.5 g IV every 8 hours
    3. Urinary Tract Infections: Treated for 7-14 days
    4. Intraabdominal infections
      1. Treat for 5 to 14 days
      2. Combine with Metronidazole

VI. Precautions

  1. Avoid Avibactam in pregnancy (adverse effects in pregnancy)
  2. Ceftazidime is excreted in Breast Milk

VII. Disadvantages

  1. Most expensive
  2. Limited spectrum

VIII. Adverse Effects

IX. References

  1. Morrison and LoVecchio (2021) Crit Dec Emerg Med 35(1): 28

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