III. Mechanism

  1. Interferes with Cytokine signalling on receptor binding

IV. Preparations

  1. Ruxolitinib or Jakafi (JAK1 and JAK2 Inhibitor)
    1. Indicated in Rheumatoid Arthritis and Myelofibrosis (including Polycythemia Vera)
  2. Baricitinib or Olumiant (JAK1 and JAK2 inhibitor)
    1. Indicated in Rheumatoid Arthritis
  3. Upadacitinib or Rinvoq (JAK1 inhibitor)
    1. Indicated in Rheumatoid Arthritis
  4. Tofacitinib or Xeljanz (JAK3 Inhibitor)
    1. Indicated in Rheumatoid Arthritis and Psoriasis
    2. Multiple black box warnings
      1. Serious infections
      2. Thrombosis (e.g. Venous Thromboembolism)
      3. Cardiovascular events (e.g. Myocardial Infarction)
      4. Lung Cancer
      5. Increased mortality
    3. References
      1. (2021) Presc Lett 28(4): 22

V. Adverse Effects

  1. Venous Thromboembolism
  2. Sudden cardiovascular death (associated with Tofacitinib)
  3. Immunosuppression
    1. Tuberculosis reactivation risk
    2. Increased risk of Pneumonia, Shingles

VI. Precautions

  1. Avoid Live Vaccines

VII. References

  1. (2019) Presc Lett 26(10): 58

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Related Studies

Cost: Medications

xeljanz (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
XELJANZ 5 MG TABLET $60.77 each
XELJANZ XR 11 MG TABLET $121.33 each

Ontology: Janus kinase (C0597721)

Definition (CSP) nonEC; family of cytoplasmic protein tyrosine kinases.
Definition (MSH) A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS. They act upon STAT TRANSCRIPTION FACTORS in signaling pathway referred to as the JAK/STAT pathway. The name Janus kinase refers to the fact the proteins have two phosphate-transferring domains.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D053612
English JAK Kinases, Janus Kinases, Kinases, JAK, Kinases, Janus, JAK kinase, Janus kinase, Janus Kinases [Chemical/Ingredient]
Portuguese Janus Quinases, Janus-Quinases, Quinases Janus
Spanish Quinasas Janus, Janus-Cinasas, Janus Quinasas, Cinasas Janus, Janus Cinasas, Janus-Quinasas
Italian Chinasi Giano, Jak chinasi
German JAK-Kinasen, Janus-Kinasen
French Janus kinases, Tyrosine-kinases JAK, Tyrosine kinases JAK, JAK Kinases, Kinases JAK, Protéines tyrosine kinases JAK
Finnish Janus-kinaasit
Czech kinasy JAK, Janus kinasy, JAK kinasy
Japanese ヤヌスキナーゼ
Swedish Januskinaser
Polish Kinazy JAK