II. Indications
- Prevention of Dental Caries in children
- Use when water supply has inadequate fluoride
-
Osteoporosis Prevention
- No longer recommended (previously recommended for adults at risk at 25 mg daily)
III. Precautions
- Narrow Therapeutic Index: Too high dosing effects
- In areas with very high fluoride water concentration:
- Pregnant women and children should use bottled water
- Well water
- Fluoride is naturally occurring in soil, rock and water, and varies widely by location
- Private well water is not regulated and requires testing to determine fluoride levels (which may be high)
IV. Dosing Schedule for children for Dental Caries prevention
- Fluoride ion levels in drinking water
- Parts Per Million (ppm): 1.0 ppm = 1 mg/Liter
- Sodium Fluoride 2.2 mg contains 1 mg of fluoride ions
- Ages 6 months to 3 years old
- Local Water Fluoride <0.3 ppm: Fluoride 0.25 mg qd
- Local Water Fluoride 0.3-0.7 ppm: No Fluoride
- Local Water Fluoride >0.7 ppm: No Fluoride
- Ages 3 to 6 years old
- Local Water Fluoride <0.3 ppm: Fluoride 0.50 mg qd
- Local Water Fluoride 0.3-0.7 ppm: Fluoride 0.25 mg qd
- Local Water Fluoride >0.7 ppm: No Fluoride Supplement
- Ages 6 to 16 years old
- Local Water Fluoride <0.3 ppm: Fluoride 1.00 mg qd
- Local Water Fluoride 0.3-0.7 ppm: Fluoride 0.50 mg qd
- Local Water Fluoride >0.7 ppm: No Fluoride
V. Efficacy
- Prevents Dental Caries
- Initially thought to prevent osteoporotic Fractures if started early and in low doses
- Found to increase bone density 10% per year
- However resulting bone is not thought to be as strong, and may not confer advantage in Osteoporosis Prevention
VI. Preparations
- Drops: 0.125 mg, 0.25 mg and 0.5 mg per dropper
- Chewable tablets: 0.5 mg, 1 mg
- Tablets: 1 mg
- Multi-Vitamins (Tri-vi-flor and poly-vi-flor)
- Available as drops and chewable tablets
- Write specifically for older, generic formulation (another pharmaceutical switch to re-patent an old drug)
- Fluoride varnish (applied at dental visits, in addition to oral Fluoride Supplementation as needed)
- Fluoride varnish is also applied to teeth at each pediatric dental visits after Tooth Eruption (6 months)
- See Oral Health in Children
- Sievers (2016) Am Fam Physician 93(9):743-4 [PubMed]
VII. Resources
- My Water's Fluoride (CDC)
VIII. References
Images: Related links to external sites (from Bing)
Related Studies
| sodium fluoride (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| SODIUM FLUORIDE 0.2% RINSE | Generic | $0.02 per ml |
| SODIUM FLUORIDE 0.25 (0.55) MG | Generic | $0.07 each |
| SODIUM FLUORIDE 0.5 MG(1.1 MG) | Generic | $0.08 each |
| SODIUM FLUORIDE 0.5 MG/ML DROP | Generic | $0.22 per ml |
| SODIUM FLUORIDE 1 MG (2.2 MG) | Generic | $0.07 each |
| SODIUM FLUORIDE 1.1% GEL | Generic | $0.13 per gram |
| SODIUM FLUORIDE 5000 DRY MOUTH | Generic | $0.12 per ml |
| SODIUM FLUORIDE 5000 PLUS CRM | Generic | $0.09 per gram |
| SODIUM FLUORIDE 5000 PPM CREAM | Generic | $0.09 per gram |
| SODIUM FLUORIDE 5000 PPM PASTE | Generic | $0.12 per ml |
| SODIUM FLUORIDE SENSTV 5000PPM | Generic | $0.11 per ml |
Ontology: Sodium Fluoride (C0037508)
| Definition (NCI) | An inorganic salt of fluoride used topically or in municipal water fluoridation systems to prevent dental caries. Fluoride appears to bind to calcium ions in the hydroxyapatite of surface tooth enamel, preventing corrosion of tooth enamel by acids. This agent may also inhibit acid production by commensal oral bacteria. (NCI04) |
| Definition (MSH) | A source of inorganic fluoride which is used topically to prevent dental caries. |
| Definition (PDQ) | An inorganic salt of fluoride used topically or in municipal water fluoridation systems to prevent dental caries. Fluoride appears to bind to calcium ions in the hydroxyapatite of surface tooth enamel, preventing corrosion of tooth enamel by acids. This agent may also inhibit acid production by commensal oral bacteria. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39598&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39598&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C832" NCI Thesaurus) |
| Concepts | Biomedical or Dental Material (T122) , Inorganic Chemical (T197) |
| MSH | D012969 |
| SnomedCT | 6910009, 329199009 |
| HL7 | NAF |
| English | Fluoride, Sodium, Sodium Fluoride, Sodium fluoride (NaF), sodium fluoride preparations, sodium fluoride preparations (medication), sodium fluoride (medication), dental preparations sodium fluoride preparations, fluoride (as sodium fluoride), NaF, SODIUM FLUORIDE, Sodium Fluoride [Chemical/Ingredient], sodium fluoride, Fluorides, Sodium, Sodium Fluorides, fluoride sodium, Fluoride, sodium, Sodium Fluoride (NaF), Sodium fluoride, Sodium fluoride (substance), Sodium fluoride product (product), Sodium fluoride product, Sodium fluoride product (substance), FLUORIDE (AS SODIUM FLUORIDE), FLUORIDE (AS SODIUM), Fluoride Sodium |
| French | Fluorure de sodium |
| Swedish | Natriumfluorid |
| Spanish | fluoruro de sodio, producto, fluoruro de sodio (producto), producto con fluoruro de sodio (producto), producto con fluoruro de sodio, fluoruro de sodio (sustancia), fluoruro de sodio, fluoruro de sodio, producto (producto), Fluoruro de Sodio |
| Czech | fluorid sodný |
| Finnish | Natriumfluoridi |
| Russian | NATRIIA FTORID, NATRII FTORISTYI, НАТРИЙ ФТОРИСТЫЙ, НАТРИЯ ФТОРИД |
| Japanese | フッ化ナトリウム, ふっ化ナトリウム, 弗化ナトリウム |
| Polish | Fluorek sodowy |
| Norwegian | Natriumfluorid |
| German | Natriumfluorid |
| Italian | Floruro di sodio |
| Portuguese | Fluoreto de Sódio |
