II. Indications
III. Contraindications
- Age <12 years
- Weight <35 kg (77 lb)
IV. Mechanism
- Spiropyrimidinetrione, a new class of Antibiotics
- Bactericidal Antibiotic that inhibits DNA synthesis
- Inhibits Bacterial type II topoisomerases (DNA gyrase and topoisomerase IV)
- Binds different sites than Fluoroquinolones
V. Dosing
- Take one dose of 3 grams (oral suspension)
- Taken with 60 ml water and within 15 minutes of preparation
- Administration instructions depends on weight
- Weight <50 kg: Take on empty Stomach, 1 hour before or 2 hours after eating
- Weight >50k: Take with food
VI. Drug Interactions
- Moderate to strong CYP 3A4 inducers (e.g. Rifampin, Carbamazepine)
- Avoid using Zoliflodacin
VII. Safety
- Unknown safety in Lactation
- Unknown safety in pregnancy
- Adverse effects in animal studies
- Adverse effects include if male partners take Zoliflodacin within last 3 months
IX. Efficacy
- Less effective than Ceftriaxone and Azithromycin, or Cefixime
- WHO recommends only agents with 95% cure rates, which Zoliflodacin does not meet
X. Resources
- Zoliflodacin (DailyMed)