II. Indications

  1. Methicillin-Resistant Staphylococcus aureus (MRSA)
  2. Complicated Skin Infections
  3. Do not use for Pneumonia
    1. Poorly penetrates lung
    2. Inactivated by surfactant

III. Mechanism

  1. Cyclic Lipopeptide
  2. Depolarizes Bacterial cell membranes

IV. Preparations

  1. Intravenous daily dosing

V. Dosing: Adults

  1. Daptomycin 4 mg/kg in NS over 30 minutes once daily

VI. Adverse Effects

  1. Muscle toxicity (avoid concurrent Statin use)

VII. Monitoring

  1. Obtain serum CPK level weekly while on Daptomycin

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