II. Indications
- Prevention of Motion-Induced Vomiting (Motion Sickness)
III. Mechanism
- See Neurokinin-1 Receptor Antagonist
- Blocks the neurokinin-1 receptor (a tachykinin)
- Crosses the blood brain barrier to inhibit CNS Substance-P activity, reducing Motion-Induced Vomiting
IV. Dosing
- Tradipitant 85-170 mg orally 60 minutes before triggering event (e.g. boating)
- Take on an empty Stomach
- Do not repeat dosing for 24 hours
VI. Adverse Effects
- Minimal sedation (contrast with Antihistamines such as Meclizine)
- Expensive (in 2026, each 85 capsule costs $255)
VII. Drug Interactions
- Strong CYP3A4 Inhibitors (e.g. Clarithromycin)
- Increases Tradipitant adverse effects
VIII. Resources
IX. References
- (2026) Presc Lett 33(6): 5-6