II. Background
- Ulcerative Colitis and Crohns Disease share similar extraintestinal manifestations
- However extraintestinal findings are more common with Crohn's Disease
III. Associated Conditions: Musculoskeletal
- Osteoporosis (15% of UC, >2% of CD)
- Inflammatory Arthropathy, Colitic Arthritis or Arthralgias (5-21% of UC, >10% of CD)
- Ankylosing Spondylitis (2% of UC)
IV. Associated Conditions: Ocular
- Episcleritis (parallels Ulcerative Colitis course, occurs in 29% of CD)
- Scleritis (18% of CD)
-
Anterior Uveitis (3-4% of UC, 17% of CD)
- Variable course
- Associated with Enteropathic Arthritis
- Recurrent Iritis
V. Associated Conditions: Dermatologic
- Digital Clubbing (presence increases likelihood of Ulcerative Colitis)
-
Erythema Nodosum (3% of UC, >2% of CD)
- Parallels Ulcerative Colitis course
- Pyoderma Gangrenosum (up to 2% of UC, >0.5% of CD)
- Lichen Planus
- Aphthous Stomatitis, Aphthous Ulcers or Canker Sores (4% of UC)
- Psoriasis (1% of UC)
VI. Associated Conditions: Hepatobiliary
- Hepatic Steatosis
-
Primary Sclerosing Cholangitis (4-5% co-Incidence in UC)
- Occurs in as many as 2.5 to 7.5% of Ulcerative Colitis patients
- Progresses to Cirrhosis and liver failure in most patients
- Cholelithiasis (>13% in CD)
- Pericholangitis
VII. Associated Conditions: Miscellaneous
- See Gynecologic Manifestations of Crohn's Disease
- Anemia (>9% of CD)
- Aphthous Stomatitis (>4%)
- Nephrolithiasis and Ureteral Stones (>8% of CD)
-
Venous Thromboembolism (DVT/PE in 0.3% of UC, >10% of CD)
- Deep Vein Thrombosis or Pulmonary Embolism in 0.3% of UC cases