II. Background

  1. First approved for use in U.S. in 1958
  2. Synthetic butylamino-benzoate derivative (related to tetracaine, procaine)
    1. Voltage-gated Sodium channel inhibitor
  3. Peripherally acting non-opioid Antitussive
  4. Decreases cough reflex by anesthetizing and suppressing stretch receptors receptors in the airways, lungs, and pleura
  5. Narrow therapeutic range
    1. See Benzonatate Overdose
    2. Single capsule may be lethal in a child
    3. A small handful of capsules in Overdose could be lethal in adults

III. Dosing

  1. Adults: 100-200 mg orally every 8 hours as needed for cough
  2. Not approved for age under 10 years old

IV. Pharmacokinetics

  1. Onset: 15-20 minutes
  2. Duration: 3-8 hours

V. Adverse Effects

  1. Nausea
  2. Dizziness
  3. Headache
  4. Sedation or Somnolence
  5. Tongue numbness

VI. Precautions: Toxicology

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Related Studies

Cost: Medications

benzonatate (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
BENZONATATE 100 MG CAPSULE Generic $0.08 each
BENZONATATE 200 MG CAPSULE Generic $0.11 each
BENZONATATE PERLE 100 MG CAP Generic $0.08 each