II. Mechanism

  1. Decreases Bacterial cell wall synthesis
  2. Similar coverage and mechanism to Vancomycin
  3. Long-acting agents, with a single Parenteral dose covering entire antibiotic course

III. Indications

  1. Refractory Skin and Soft Tissue Infections with failure to respond to maximal oral antibiotic coverage

IV. Preparations

  1. Dalbavancin (Dalvance)
    1. Infused over 30 minutes weekly
  2. Oritavancin (Orbactiv)
    1. Infused over 3 hours
    2. Single dose may be sufficient for MRSA Cellulitis
    3. Contraindicated with Warfarin or Heparin use

V. Disadvantages

  1. Expensive ($2500 to $9500 per single dose)

VI. References

  1. (2014) Presc Lett 21(8): 43

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