II. Mechanism
- Decreases Bacterial cell wall synthesis
- Similar coverage and mechanism to Vancomycin
- Long-acting agents, with a single Parenteral dose covering entire antibiotic course
III. Indications
- Refractory Skin and Soft Tissue Infections with failure to respond to maximal oral antibiotic coverage
IV. Preparations
- Dalbavancin (Dalvance)
- Infused over 30 minutes weekly
- Oritavancin (Orbactiv)
- Infused over 3 hours
- Single dose may be sufficient for MRSA Cellulitis
- Contraindicated with Warfarin or Heparin use
V. Disadvantages
- Expensive ($2500 to $9500 per single dose)
VI. References
- (2014) Presc Lett 21(8): 43