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Haloperidol

Aka: Haloperidol, Haldol, Haloperidol Lactate, Haloperidol decanoate
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  1. Indications
    1. Psychosis
    2. Delirium
    3. Schizophrenia
    4. Tic Disorders (including Tourette's Syndrome)
    5. Acute Mania
  2. Contraindications
    1. Pregnancy and Lactation
    2. Phencyclidine (PCP) overdose
    3. Anticholinergic syndromes
    4. Alcohol or Benzodiazepine Withdrawal
    5. Hepatic Insufficiency
    6. Neuroleptic Malignant Syndrome
  3. Class
    1. First Generation Antipsychotic
  4. Dosing: Haloperidol
    1. Dose
      1. Adult: 5-10 mg PO, IM, or IV
      2. Peds: 0.5-1 mg PO, IM or IV
      3. Adolescent: 1-5 mg PO, IM or IV
      4. Elderly: 0.5-2 mg PO, IM or IV
    2. Intervals: Scheduled and repeated dosing intervals
      1. May repeat every 30-60 minutes
      2. Maximum: 300 mg/24 hours (avoid cummulative dose over 100 mg in 24 hours)
      3. May dose regularly every 6-8 hours
        1. Typical effective dose: 5 mg PO, IV, or IM tid (lower doses in the elderly)
      4. Total dose >3 mg/day is associated with Extrapyramidal Side Effects
  5. Dosing: Haloperidol decanoate (depot form)
    1. Haloperidol decanoate 100 mg IM every 4 weeks
    2. Cost effective (may be as low as $19 generic)
  6. Precautions
    1. Intravenous doses have a much shorter duration of action than other routes
    2. Antipsychotics are associated with increased mortality in the elderly
  7. Adverse effects
    1. Serious
      1. See Extrapyramidal Side Effects (EPSE)
      2. Neuroleptic Malignant Syndrome
      3. Hypotension
      4. Dystonia
      5. Seizures
      6. Prolonged QT interval
        1. Risk of Torsades de Pointes
        2. Dose related effect with higher risk at higher doses
    2. Common
      1. Insomnia
      2. Restlessness
      3. Anxiety
      4. Sedation
      5. Headache
      6. Weight gain
      7. Hyperprolactinemia
      8. Blood dyscrasia
  8. Monitoring
    1. Serum Prolactin
      1. Obtain if indicated
    2. Complete Blood Count (indicated if history of Leukopenia)
      1. Baseline
      2. Monthly in first 3 months of therapy
Medication Costs
HALOPERIDOL (on 2/10/2012 at Target.com)
HALOPERIDOL 0.5 MG Tablet #30 for $4.00 ($0.13/unit)
HALOPERIDOL 1 MG Tablet #30 for $4.00 ($0.13/unit)
HALOPERIDOL 2 MG Tablet #30 for $4.00 ($0.13/unit)
HALOPERIDOL 5 MG Tablet #30 for $4.00 ($0.13/unit)
Haloperidol (on 2/9/2012 at DrugStore.com)
Haloperidol 2mg Tablets #90 for $20.99 ($0.23/unit)
Haloperidol 1mg Tablets #90 for $19.99 ($0.22/unit)
Haloperidol 5mg Tablets #90 for $25.99 ($0.29/unit)
Haloperidol 0.5mg Tablets #90 for $16.99 ($0.19/unit)
Haloperidol 20mg Tablets #60 for $124.99 ($2.08/unit)
Haloperidol 10mg Tablets #60 for $72.99 ($1.22/unit)
Haloperidol Decanoate (on 2/9/2012 at DrugStore.com)
Haloperidol Decanoate 100mg/ml Solution 1ml Vial #1 for $50.99 ($50.99/unit)
Haloperidol Decanoate 100mg/ml Solution #5 for $225.98 ($45.20/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Haloperidol (C0018546)

Definition (NCI) A phenylbutylpiperadine derivative with antipsychotic, neuroleptic, and antiemetic activities. Haloperidol competitively blocks postsynaptic dopamine (D2) receptors in the mesolimbic system of the brain, thereby eliminating dopamine neurotransmission and leading to antidelusionary and antihallucinagenic effects. Antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) accounts for its antiemetic activity.
Definition (NCI) A drug used to treat certain mental and neurological disorders. It is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of antiemetic and a type of antipsychotic.
Definition (MSH) A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
Definition (CSP) USP lists as an antipsychotic and as an "antidyskinetic" used in Tourette syndrome.
Definition (PDQ) A phenylbutylpiperadine derivative with antipsychotic, neuroleptic and antiemetic effects. Haloperidol competitively blocks postsynaptic dopamine (D2) receptors in the mesolimbic system of the brain, thereby eliminating dopamine neurotransmission and leading to antidelusionary and antihallucinagenic effects. The antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) accounts for its antiemetic activity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39474&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39474&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C537" NCI Thesaurus)
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D006220
SnomedCT 321415008, 323259009, 10756001, 386837002
English Haloperidol, haloperidol, 1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-, Haloperidol [antipsychotic], Haloperidol [tics, chorea], Haloperidol [tics, chorea] [see D47..], 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone, HALOPERIDOL, Haloperidol [tics, chorea] [see D47..] (product), Haloperidol [antipsychotic] (product), haloperidol (medication), Haloperidol [Chemical/Ingredient], Haloperidol (product), Haloperidol (substance), Haloperidol [antipsychotic] (substance), Haloperidol [tics, chorea] [see D47..] (substance)
Swedish Haloperidol
Czech haloperidol
Finnish Haloperidoli
Russian GALOPERIDOL, ГАЛОПЕРИДОЛ
Spanish haloperidol [tics, corea] [véase D47..], haloperidol [antipsicótico] (producto), haloperidol [antipsicótico], haloperidol [tics, corea] [véase D47..] (producto), haloperidol (producto), haloperidol (sustancia), haloperidol, Haloperidol
Japanese ハロペリドール
Croatian HALOPERIDOL
Polish Haloperidol
French Halopéridol
German Haloperidol
Italian Aloperidolo
Portuguese Haloperidol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


haloperidol decanoate (C0062103)

Definition (NCI) The decanoate ester of haloperidol, a phenylbutylpiperadine derivative with antipsychotic, neuroleptic and antiemetic effects. Haloperidol competitively blocks postsynaptic dopamine (D2) receptors in the mesolimbic system of the brain leading to anti-delusionary and anti-hallucinogenic effects. The antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) account for its antiemetic activity.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C033563
SnomedCT 412196004, 321699007
English haloperidol decanoate, Haloperidol Decanoate, Haloperidol deconoate, haloperidol decanoate (discontinued) (medication), haloperidol decanoate (discontinued), haloperidol decanoate [Chemical/Ingredient], HALOPERIDOL DECANOATE, Haloperidol decanoate, Haloperidol decanoate (product), Haloperidol decanoate (substance), Haloperidol deconoate (substance)
Spanish decanoato de haloperidol (producto), decanoato de haloperidol, decanoato de haloperidol (sustancia)
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Haldol (C0591585)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D006220
English Haldol, haldol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Haloperidol lactate (C0720809)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
SnomedCT 412197008
English haloperidol lactate, haloperidol lactate (medication), Haloperidol lactate, HALOPERIDOL LACTATE, Haloperidol lactate (substance), Haloperidol Lactate
Spanish lactato de haloperidol (sustancia), lactato de haloperidol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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