II. Indications
III. Mechanism
- See Mitotic Inhibitor Chemotherapy
- Vinblastine, like Vincristine, is a natural Vinca Alkaloid with antineoplastic activity
- Isolated from the periwinkle plant (Vinca rosea Linn)
- Vinblastine is antitubular agent
- Binds tubulin and inhibits microtubule formation
- Disrupts mitotic spindle formation
- Arrests cell cycle in M phase
- Other possible activity
- Interferes with metabolism of Amino Acids cAMP, glutathione
- Interferes with calmodulin-dependent Calcium transport ATPase activity
- Interferes with biosynthesis of Nucleic Acids and lipids
IV. Medications
- Vinblastine injection solution: 1 mg/ml in 10 mg vials
V. Dosing
- See other references for disease specific dosing protocols
VI. Adverse Effects
- Impaired future fertility
- Alopecia
- Bronchospasm
- Severe skin and soft tissue necrosis on extravasation
-
Peripheral Neuropathy
- Less than Vincristine
- Myelosuppression (Bone Marrow suppression)
- Leukopenia
- More myelosuppression than Vincristine
VII. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
VIII. Drug Interactions
- Drug levels decreased by Vinblastine
- Increased Vinblastine levels and toxicity
- CYP3A4 Inhibitors (e.g. Ketoconazole, Erythromycin)
IX. Resources
- Vinblastine Sulfate Injection (DailyMed)