II. Indications
- FDA Approved (combined with other agents)
- Off-Label
III. Mechanism
- See Mitotic Inhibitor Chemotherapy
- Vincristine, like Vinblastine, is a natural Vinca Alkaloid with antineoplastic activity
- Isolated from the periwinkle plant (Vinca rosea Linn)
- Vincristine is an antitubular agent
- Binds tubulin and inhibits microtubule formation
- Disrupts mitotic spindle formation
- Arrests cell cycle in G2/M phase
- Other possible activity
- Interferes with metabolism of Amino Acids cAMP, glutathione
- Interferes with calmodulin-dependent Calcium transport ATPase activity
- Interferes with biosynthesis of Nucleic Acids and lipids
IV. Medications
- Vincristine intravenous solution: 1 mg/ml in 1 and 2 ml vials
V. Dosing
- See other references for disease specific dosing protocols
VI. Adverse Effects
- Impaired future fertility
- Alopecia
- Bronchospasm
- Central Nervous System Toxicity
- Hyperuricemia
- Hypersensitivity Reaction
- Severe skin and soft tissue necrosis on extravasation
- Myelosuppression (Bone Marrow suppression)
- Minimal compared with other agents (e.g. Vinblastine)
-
Peripheral Neuropathy
- More than Vinblastine
VII. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
- Monitoring
IX. Resources
- Vincristine Injection Solution (DailyMed)
- Vincristine (StatPearls)