Gynecology Book

http://www.fpnotebook.com/

Gonadotropin-releasing Hormone AgonistAka: GnRH agonist, Nafarelin Acetate, Synarel

Advertisement

  1. Indication
    1. Endometriosis
  2. Pathophysiology
    1. Potentiates Gonadotropin-releasing hormone (GnRH)
    2. Results in hypoestrogenism or pseudo-Menopause
    3. Does not cause the same androgenic effects as Danazol
  3. Dosing: Nafarelin acetate (Synarel)
    1. Synarel 200-400 micro-g intranasally bid
  4. Efficacy
    1. Effective at regression of lesions and relief of pain
    2. No proven effect on fertility
  5. Adverse effects
    1. Menopausal symptoms
      1. Hot Flashes
      2. Insomnia
      3. Emotional changes
    2. Bone density loss with prolonged use

Synarel (C0131793)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSHD017274
EnglishSynarel
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



Navigation Tree