Gynecology Book

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Estrogen

Aka: Estrogen, Ethinyl Estradiol, Mestranol
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  1. See Also
    1. Estrogen Replacement Therapy (Hormone Replacement)
    2. Oral Contraceptive
  2. Symptoms of Excess Estrogen (e.g. Premenstrual Syndrome)
    1. Swollen or engorged Breast tenderness
    2. Water retention
    3. Irritability
    4. Headaches
    5. Visual disturbance
    6. Memory difficulty
    7. Sweet craving
  3. Relative Potency
    1. Ethinyl Estradiol: 100
    2. Mestranol: 67
  4. Precautions
    1. Mestranol is potentially a carcinogen (animal studies)
    2. MI, CVA, DVT, PE and Breast Cancer risk are all FDA Black box warnings
  5. Preparations: Hormone Replacement dosage
    1. Ethinyl Estradiol
      1. Hormone Replacement: 0.005 to 0.02 mg/day
      2. Oral Contraceptive: 0.03 to 0.10 mg/day
    2. Micronized estradiol (1-2 mg/day)
    3. Estradiol Cypionate (2-5 mg every 3-4 weeks)
    4. Estradiol valerate (2-20 mg every other week)
    5. Estropipate (1.25-2.5 mg/day)
    6. Conjugated Estrogen (e.g. Premarin)
      1. Oral (0.3-1.25 mg/day)
      2. Injectable (0.2-2 mg/day)
      3. Transdermal
    7. Diethylstilbestrol (0.1-0.5 mg/day)
    8. Quinestrol (0.1-0.2 mg/week)
    9. Chlorotrianisene (12-25 mg/day)
    10. Methallenestril (3-9 mg/day)
    11. Esterified Estrogen (Menest): 0.3 to 1.25 mg/day
Medication Costs
Delestrogen (on 2/9/2012 at DrugStore.com)
Delestrogen 10mg/ml Oil #5 for $79.99 ($16.00/unit)
Delestrogen 20mg/ml Oil #5 for $111.99 ($22.40/unit)
Delestrogen 40mg/ml Oil #5 for $185.99 ($37.20/unit)
Est Estrogens-Methyltest HS (on 2/9/2012 at DrugStore.com)
Est Estrogens-Methyltest HS 0.625-1.25mg Tablets #30 for $49.31 ($1.64/unit)
Est Estrogens-Methyltest (on 2/9/2012 at DrugStore.com)
Est Estrogens-Methyltest 1.25-2.5mg Tablets #30 for $40.99 ($1.37/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Estrogens (C0014939)

Definition (NCI) A type of hormone made by the body that helps develop and maintain female sex characteristics and the growth of long bones. Estrogens can also be made in the laboratory. They may be used as a type of birth control and to treat symptoms of menopause, menstrual disorders, osteoporosis, and other conditions.
Definition (MSH) Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Definition (NCI) A class of natural or synthetic hormones that binds to a cytoplasmic receptor and initiates translocation of the hormone-receptor complex to the nucleus of target cells of tissues rich in estrogen receptors, including the endometrium, myometrium, oviduct, vagina, fallopian tube, cervix, brain, liver, placenta, ovarian cells, Leydigs cells, kidney, prostate, pancreas, heart, and skin. (NCI)
Definition (CSP) hormones which stimulate the female reproductive organs, and the development of secondary female sex characteristics.
Concepts Steroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
MSH D004967
SnomedCT 325478009, 41598000, 61946003
English Estrogen, Estrogens, ESTROGENIC PREPARATIONS, Estrogen preparation, Estrogen preparation, NOS, Estrogen, NOS, Estrogenic drug, NOS, Oestrogens, Oestrogen preparation, NOS, Oestrogen, NOS, Oestrogenic drug, NOS, Estrogens (product), ESTROGENS, estrogens (medication), estrogens, A09 ESTROGENIC PREPARATIONS, [HS300] ESTROGENS, oestrogen products, oestrogens, estrogen products, oestrogen, estrogen substance, estrogenic preparation, Compounds, Estrogenic, Estrogenic Compounds, Agents, Estrogenic, Estrogenic Agents, Estrogen product, Oestrogen product, Oestrogen, Estrogen (substance), Estrogenic drug, Estrogenic preparation (product), Estrogenic preparation, Oestrogenic drug, Oestrogenic preparation, estrogen, Estrogenic preparation (substance), Estrogens (substance), Therapeutic Estrogen
French Composés oestrogéniques, Composés estrogéniques, Agents estrogéniques, Agents oestrogéniques, Estrogènes, Oestrogènes
Swedish Östrogener
Spanish estrógenos, estrógenos (producto), droga estrogénica, estrógeno (sustancia), estrógeno, preparado estrogénico (producto), preparado estrogénico (sustancia), preparado estrogénico, Estrogenos, Estrógenos
Czech estrogeny
Finnish Estrogeenit
Italian Composti estrogenici, Estrogeno, Sostanze estrogeniche, Estrogeni
Russian ESTROGENY, ЭСТРОГЕНЫ
Japanese エストロゲン, 卵胞ホルモン, 卵胞ホルモン類, 発性ホルモン物質, 発情ホルモン, エストロジェン
Croatian ESTROGENI
Polish Estrogeny
German Östrogene
Portuguese Estrogênios, Estrógenos
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Mestranol (C0025506)

Definition (MSH) The 3-methyl ether of ETHINYL ESTRADIOL. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL CONTRACEPTIVES.
Definition (NCI) A semisynthetic estrogen. Metabolized by the liver to ethynyl estradiol, mestranol serves as the estrogen component in several combination oral contraceptives. (NCI04)
Concepts Steroid (T110) , Pharmacologic Substance (T121)
MSH D008656
SnomedCT 326365002, 395785001, 77885004, 126096002
English Ethinyl Estradiol 3-Methyl Ether, Mestranol, 19-Norpregna-1,3,5(10)-trien-20-yn-17-ol, 3-methoxy-, (17alpha)-, Mestranol [contraceptive], Mestranol preparation, NOS, (17alpha)-3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17-ol, ETHINYL ESTRADIOL METHYL ETHER 03, Mestranol [combined oral contraceptive], mestranol, MESTRANOL, Mestranol [combined oral contraceptive] (product), oral contraceptives mestranol preparations, mestranol preparations (medication), mestranol preparations, Mestranol [Chemical/Ingredient], Ethinyl Estradiol 3 Methyl Ether, Mestranol product, Mestranol (substance), Mestranol preparation (product), Mestranol preparation, Mestranol (product), Mestranol [combined oral contraceptive] (substance), Mestranol preparation (substance)
French Éthinyl oestradiol 3-méthyl éther, Mestranol
Swedish Mestranol
Czech mestranol
Finnish Mestranoli
Russian MESTRANOL, ETINILESTRADIOLA 3-METILOVYI EFIR, МЕСТРАНОЛ, ЭТИНИЛЭСТРАДИОЛА 3-МЕТИЛОВЫЙ ЭФИР
Spanish mestranol (anticonceptivo oral combinado) (producto), mestranol (anticonceptivo oral combinado), preparado con mestranol (producto), mestranol (producto), preparado con mestranol, mestranol (sustancia), mestranol, preparado de mestranol (sustancia), Eter 3-Metil del Etinil Estradiol, Mestranol, Éter 3-Metil del Etinil Estradiol
Japanese エチニルエストラジオール3-メチルエーテル, メストラノール
Polish Mestranol
German Mestranol
Italian Mestranolo
Portuguese Etinil Estradiol 3-Metil Éter, Mestranol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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