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Danazol
Aka: Danazol- Indications
- Pathophysiology
- Synthetic isoxazol derivative of ethisterone
- Inhibits gonadotropic secretion
- Prevents Menstrual Bleeding
- Mildly androgenic
- Dosing
- Danazol 400-600 mg qd
- Efficacy
- Expensive ($100/month)
- Same rate of pregnancy as with Provera or Surgery
- Adverse Effects: Androgenic effects
- Acne Vulgaris
- Flushes
- Sweats
- Edema
- Libido changes
| Medication Costs | ||
|---|---|---|
| Danazol (on 2/9/2012 at DrugStore.com) | ||
| Danazol 50mg Capsules | #30 for $55.99 | ($1.87/unit) |
| Danazol 100mg Capsules | #30 for $69.99 | ($2.33/unit) |
| Danazol 200mg Capsules | #30 for $110.76 | ($3.69/unit) |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Danazol (C0010961) |
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|---|---|
| Definition (MSH) | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. |
| Definition (NCI) | A synthetic androgen derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. (NCI04) |
| Definition (NCI) | A synthetic hormone that belongs to the family of drugs called androgens and is used to treat endometriosis. It is being evaluated in the treatment of endometrial cancer. |
| Definition (PDQ) | A synthetic androgen derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39204&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39204&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C414" NCI Thesaurus) |
| Concepts | Steroid (T110) , Pharmacologic Substance (T121) , Hormone (T125) |
| MSH | D003613 |
| SnomedCT | 87881000, 126124009 |
| English | Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol, (17alpha)-, 17Alpha-ethynyl-17beta-hydroxy-4-androsteno[2,3-d]isoxazole, 1-Ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1H-cyclopental[7,8]phenanthro[3,2-d]isoxazol-1-ol, (17Alpha)-pregna-2,4-dien-20-yno[2,3-d]-isoxazol-17-ol, (17alpha)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol, danazol, DAN, danazol (medication), Danazol [Chemical/Ingredient], DANAZOL, Danazol preparation, Danazol product, Danazol (substance), Danazol preparation (product), Danazol preparation (substance), Danazol |
| Swedish | Danazol |
| Czech | danazol |
| Finnish | Danatsoli |
| Russian | DANAZOL, ДАНАЗОЛ |
| Japanese | ダナゾール |
| Spanish | danazol (producto), preparado con danazol (producto), preparado con danazol, danazol (sustancia), danazol, preparado de danazol (producto), preparado de danazol (sustancia), preparado de danazol, Danazol |
| Polish | Danazol |
| French | Danazol |
| German | Danazol |
| Italian | Danazolo |
| Portuguese | Danazol |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |