Filoviridae

Aka: Filoviridae, Filovirus, Filoviridae Infection, Filovirus Infection

advertisement

II. Pathophysiology

  1. Filoviridae are a family of viruses causing Viral Hemorrhagic Fever
    1. Filoviridae cause Viral Hemorrhagic Fever in Sub-Sahara Africa with high mortality (50-80%)
    2. Filoviridae are Enveloped, helical single stranded RNA Viruses
    3. Filoviridae infect pigs, bats and primates (including humans)
    4. Filamentous shaped viruses
      1. Name derived from the latin "Filo, meaning filament
  2. Transmission
    1. Direct contact with body secretions (blood, vomit, urine, stool, semen)
  3. Filoviridae are Anti-Message Sense RNA Viruses (Negative Stranded, -ssRNA)
    1. Anti-Message sense RNA (-ssRNA) need to first be transcribed into +ssRNA
    2. RNA dependent RNA Polymerase (RNA replicase, RdRp)
      1. RdRp is an enzyme carried by the -ssRNA virus within its capsid
      2. RdRp transcribes -ssRNA into +ssRNA within the host cell
    3. Translation follows +ssRNA transcription from -ssRNA (by RdRp)
      1. As with mRNA, +ssRNA translated by host ribosomes into Protein

III. Types

  1. Ebola Virus
  2. Marburg Virus

IV. Resources

  1. Filoviruses (StatPearls)
    1. https://www.ncbi.nlm.nih.gov/books/NBK544258/

V. References

  1. Gladwin, Trattler and Mahan (2014) Clinical Microbiology, Medmaster, Fl, p. 305-13

Images: Related links to external sites (from Bing)

These images are a random sampling from a Bing search on the term "Filoviridae." Click on the image (or right click) to open the source website in a new browser window. Search Bing for all related images

Related Topics in Viral Infection

advertisement