Endometrial Biopsy Interpretation

Aka: Endometrial Biopsy Interpretation

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II. Indications

  1. Abnormal Uterine Bleeding

III. Interpretation: Biopsy Results - Uninterpretable

  1. Insufficient sample occurs in up to 31-51% of cases
  2. No tissue in sample occurs in 11% of samples

IV. Interpretation: Biopsy Results - Normal

  1. Atrophic endometrium
  2. Proliferative endometrium
  3. Secretory endometrium

V. Indications: Biopsy Results - Abnormal

  1. Endometrial Cancer
  2. Endometrial Hyperplasia
    1. Cystic hyperplasia (rarely progresses to cancer)
      1. No treatment necessary
    2. Adenomatous hyperplasia (10% progresses to cancer)
      1. Intermittent or continuous Progestin
      2. Repeat biopsy in 3 to 6 months
    3. Atypical Adenomatous hyperplasia (25-50% progress)
      1. No future pregnancy planned
        1. Hysterectomy
      2. Future Fertility desired
        1. Consult with gynecology due to high risk
        2. High dose continuous Progestin
        3. Resample every 6 months

VI. References

  1. Williams (2020) Am Fam Physician 101(9): 551-6 [PubMed]

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