II. Mechanism
- Semifluorinated alkane that is water-free and preservative-free
- Forms stable, moisture retaining layer over the eye surface
- Decreases tear evaporation and stabilizes tear film
III. Dosing
- On drop instilled 4 times daily
- Wait at least 3-5 minutes when using other ophthalmic drops
IV. Adverse Effects
- Well tolerated without serious adverse effects
- Blurred Vision and Conjunctival redness occur in 1-3% of patients (similar to saline drops)
- Very expensive ($800 per month in 2025)
- Contrast with artificial tears ($10/month)
V. Drug Interactions
-
Contact Lenses
- Do not use Perfluorohexyloctane (Miebo) with Contact Lenses in place
- Remove Contact Lenses before instilling drops
- Wait at least 30 minutes before placing Contact Lenses
VI. Safety
- Unknown safety in pregnancy
- Unknown safety in age <18 years (has not been studied as of release in 2025)