Infectious Disease Book

http://www.fpnotebook.com/

Immunoglobulin

Aka: Immunoglobulin, Antibody, Monoclonal Antibody, Fragment Antigen Binding, Fragment Crystallizable, Ligand
Advertisement
  1. Definitions
    1. Fragment Antigen Binding (Fab)
      1. Antibody region that recognizes and binds antigens
    2. Fragment Crystallizable (Fc)
      1. Antibody region that interacts with immune system components
      2. Endogenous Fc triggers Natural Killer Cells and complement cascade
      3. Synthetic monoclonal antibodies may bind Fc to toxins or radioisotopes in Chemotherapy
    3. Ligand
      1. Molecule that binds to a specific receptor
    4. Monoclonal Antibody
      1. Identical antibodies that are synthesized by a single immune cell type
      2. Synthesized in labs to be targeted at disease-specific molecules
        1. Targeted Cancer Therapy
        2. Rheumatoid Arthritis
        3. Inflammatory Bowel Disease
  2. Physiology: Immunoglobulin
    1. Structure: Immunoglobulin is composed of a 4 chain monomeric structure
      1. Two heavy chains (identical)
        1. Five heavy chain classes: M, D, E, A, and G1-4
      2. Two light chains (identical)
        1. Two light chain classes: kappa and lambda
  3. Types: Immunoglobulins
    1. IgA Immunoglobulin
    2. IgE Immunoglobulin
    3. IgM Immunoglobulin
    4. IgG Immunoglobulin
  4. References
    1. Bakerman (1984) ABCs of Interpretive Lab Data, p. 392

Antibodies (C0003241)

Definition (NCI) A type of protein made by B lymphocytes in response to a foreign substance (antigen). Each antibody only binds to a specific antigen, helping to destroy the antigen directly or by assisting white blood cells to destroy the antigen.
Definition (NCI) A protein made by plasma cells (a type of white blood cell) in response to an antigen (a substance that causes the body to make a specific immune response). Each antibody can bind to only one specific antigen. The purpose of this binding is to help destroy the antigen. Some antibodies destroy antigens directly. Others make it easier for white blood cells to destroy the antigen.
Definition (CSP) infection-fighting protein molecule in blood or secretory fluids that tags, neutralizes, and helps destroy pathogenic microorganisms such as bacteria or viruses and toxins; they are generally known as immunoglobulins, and are made and secreted by B-lymphocytes in response to stimulation by antigens; each specific antibody binds only to the specific antigen that stimulated its production.
Definition (MSH) Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSH D000906
SnomedCT 68498002
English Antibodies, Antibody, NOS, antibody, antibodies, NOS AB, Antibodies [Chemical/Ingredient], NOS Ab, Little NOS Ab, Unidentified Ab, antibodys, antibodied, antibodis, antibodi, Unidentified Antibody, Little not otherwise specified Antibody, not otherwise specified Antibody, not otherwise specified AB, Antibody, Antibody (substance), Ab
Swedish Antikroppar
Czech protilátky
Finnish Vasta-aineet
Russian ANTITELA, АНТИТЕЛА
Croatian ANTITIJELA
Latvian Not Translated[Antibodies]
Polish Przeciwciała
Spanish anticuerpo (sustancia), anticuerpo, Anticuerpos
French Anticorps
German Antikörper
Italian Anticorpi
Portuguese Anticorpos
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Ligands (C0023688)

Definition (NCI) An ion, molecule or molecular group that binds to a substance to form a larger complex. (Dr. Joseph A. Thie)
Definition (MSH) A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Definition (CSP) molecule that binds to another molecule, especially a small molecule that binds specifically to a larger molecule.
Concepts Chemical (T103)
MSH D008024
English ligand, ligands, Ligand, Ligands
French Ligands
Swedish Ligander
Czech ligandy
Finnish Ligandit
Russian LIGANDY, ЛИГАНДЫ
Croatian LIGANDI
Polish Ligandy, Addenty
German Liganden
Italian Ligandi
Portuguese Ligantes
Spanish Ligantes, Ligandos
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Navigation Tree