Infectious Disease Book

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Immunoglobulin A

Aka: Immunoglobulin A, IgA Immunoglobulin, Gamma Globulin A, IgA
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  1. Normal
    1. Range: 50-350 mg/dl
    2. Varies by age
  2. Increased IgA
    1. Lymphoproliferative disorders (e.g. Multiple Myeloma)
    2. Berger's Disease (IgA nephropathy)
    3. Chronic infection
    4. Autoimmune disorders
    5. Liver disease (e.g. Portal Cirrhosis)
    6. Henoch Schonlein Purpura
  3. Decreased IgA
    1. IgA Hypogammaglobulinemia
    2. Protein losing Enteropathy
    3. Hereditary ataxia and telangiectasia
    4. Nephrotic Syndrome
  4. References
    1. Bakerman (1984) ABCs of Lab Data, p. 252-3

Immunoglobulin A (C0020835)

Definition (MSH) Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
Definition (NCI) IgA is the immunoglobulin subclass that is associated with antibody-mediated mucosal immunity. It is secreted as dimers into the mucosa and is the most effective isotype at fixing complement by the alternative pathway, even though it lacks the ability to fix complement by the classical pathway. There are two subtypes in the human - IgA1 and IgA2.
Definition (CSP) predominant immunoglobulin in seromucous secretions such as saliva, colostrum, milk, tracheobronchial and genitourinary secretions.
Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSH D007070
SnomedCT 143330004, 46046006, 165942009
English IgA, immunoglobulin A, Immunoglobulin IgA, NOS, Immunoglobulin A, Immu Globulin,Alpha (IGA), Immunoglobulin A (procedure), Immunoglobulin A [Chemical/Ingredient], immunoglobulin a, immunoglobulin a (IgA), Immunoglobulin IgA, IgA - Immunoglobulin A, Immunoglobulin IgA (substance)
Swedish Immunglobulin A
Czech imunoglobulin A, IgA
Spanish IgA, Immunoglobulin A, inmunoglobulina IgA (sustancia), inmunoglobulina IgA, Inmunoglobulina A, Inmunoglobulinas A
Finnish Immunoglobuliini A
Russian IMMUNOGLOBULIN A, IGA, ИММУНОГЛОБУЛИН A
Italian IgA, Immunoglobulina A
Croatian IMUNOGLOBULIN A, IgA
Polish Immunoglobulina A
French IgA, Immunoglobuline A
German IgA, Immunglobulin A
Portuguese IgA, Imunoglobulina A, Imunoglobulinas A
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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