Infectious Disease Book

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Immunoglobulin G

Aka: Immunoglobulin G, IgG Immunoglobulin, Gamma Globulin G, IgG
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  1. Normal
    1. Range: 800-1500 mg/dl
    2. Varies by age
  2. Physiology
    1. Crosses maternal-fetal membrane
    2. Interacts with complement system
    3. Enhances phagocytosis by binding Macrophages and PMNs
    4. Enhance cytotoxicity by binding Natural Killer Cells
  3. Decreased
    1. Hypo-IgG
    2. Protein losing Enteropathy
    3. Nephrotic Syndrome
  4. Increased
    1. Chronic granulomatous infection
    2. Inflammation
    3. Multiple Myeloma
    4. Liver disease
    5. Infections
    6. Autoimmune disease

Immunoglobulin G (C0020852)

Definition (NCI) An immunoglobulin isotype (subclass) that characterizes secondary immune responses. This isotype is further broken down into several smaller subclasses (IgG1, IgG2a, IgG2b, IgG3 in the mouse; IgG1-4 in the human), and each subclass is differentially synthesized and secreted into the serum upon differential immune stimuli.
Definition (CSP) major immunoglobulin in normal human serum, distributed evenly between the intravascular and extravascular pools; it is the major antibody of secondary immune responses and the exclusive antitoxin class.
Definition (MSH) The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Concepts Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Immunologic Factor (T129)
MSH D007074
SnomedCT 29246005, 143328001, 165940001
English 7S Gamma Globulin, Gamma Globulin, 7S, IgG, immunoglobulin G, IgG - Immunoglobulin G, Immunoglobulin G, Immunoglobulin IgG, NOS, Immu Globulin,Gamma (IGG), GAMMA GLOBULIN 07S, Immunoglobulin G [Chemical/Ingredient], immunoglobulin g (IgG), immunoglobulin g, g immunoglobulins, Immunoglobulin IgG, Immunoglobulin IgG (substance)
Swedish Immunglobulin G
Czech imunoglobulin G, IgG
Spanish Immunoglobulin G, IgG, inmunoglobulina IgG (sustancia), inmunoglobulina IgG, Inmunoglobulina G, gammaglobulina 7S
Finnish Immunoglobuliini G
Italian IgG, Gammaglobulina 7S, Immunoglobulina G
Russian IMMUNOGLOBULIN G, GAMMA-GLOBULIN, 7S, IGG, ГАММА-ГЛОБУЛИН, 7S, ИММУНОГЛОБУЛИН G
German GAMMAGLOBULIN 07S, IgG, Immunglobulin G, Gammaglobulin, 7S-
French Gammaglobuline 7S, Globuline gamma 7S, Gamma-globuline 7S, IgG, Immunoglobuline G
Croatian IMUNOGLOBULIN G
Polish Gamma globulina 7S, Immunoglobulina G, IgG
Japanese 7Sガンマグロブリン, 免疫グロブリンG
Portuguese IgG, Imunoglobulina G, gamaglobulina 7s
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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