Rheumatoid Arthritis Antiinflammatory Medications

Aka: Rheumatoid Arthritis Antiinflammatory Medications

II. Indications: Rheumatoid Arthritis

  1. Symptom relief and improved function
  2. No change in Rheumatoid Arthritis progression
  3. DMARDs are first line agents
    1. The anti-inflammatory agents shown here are adjuncts to DMARD therapy
    2. Limit use of NSAIDs and COX2 Inhibitors once on DMARD >1 month
      1. Decrease to lowest effective dose (preferably use only as needed)
      2. Best use is limiting NSAIDS and COX2 Inhibitors for exacerbations

III. Management: First Choice

  1. NSAID (Propionic Group)
    1. Naproxen
    2. Ibuprofen
    3. Fenoprofen
  2. NSAID (Heterocyclic Group)
    1. Tolmetin
    2. Sulindac
  3. NSAID (Oxicam/Indole Group)
    1. Piroxicam
    2. Indomethacin
  4. Aspirin
  5. Prednisone 10 mg qd
    1. Use as bridge therapy to DMARDs
    2. Consider Osteoporosis prophylaxis for longterm use

IV. Management: Second Choice: Non-acetylated Salicylates

  1. Trilisate
  2. Salsalate

V. Management: Local remittive agents

  1. Indicated for Rheumatoid Arthritis flares
  2. Corticosteroid Injection

VI. References

  1. Pincus (1993) Rheum Dis Clin North Am 19:123-151 [PubMed]
  2. Scott (2010) Lancet 376(9746):1094-108 [PubMed]
  3. Wasserman (2011) Am Fam Physician 84(11): 1245-52 [PubMed]

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Related Studies

Ontology: Antirheumatic Agents (C0003191)

Definition (CSP) agent that relieves or prevents rheumatic disease, especially rheumatoid arthritis.
Definition (MSH) Drugs that are used to treat RHEUMATOID ARTHRITIS.
Concepts Pharmacologic Substance (T121)
MSH D018501
SnomedCT 88279005, 372888006
English Agents, Anti-Rheumatic, Anti-Rheumatic Agents, antirheumatic agent, Agents, Antirheumatic, Anti Rheumatic Drugs, Anti-Rheumatic Drugs, Antirheumatic Agents, Antirheumatic Drugs, Drugs, Anti-Rheumatic, Drugs, Antirheumatic, ANTIRHEUMATICS, Antirheumatic Agent, Antirheumatic, Antirheumatic Agent [TC], [MS100] ANTIRHEUMATICS, antirheumatic agents, antirheumatic, anti rheumatic drug, anti-rheumatic drugs, anti rheumatic drugs, antirheumatic drugs, antirheumatic drug, antirheumatics, Anti Rheumatic Agents, Antirheumatic agents, Anti-rheumatic agent (product), Anti-rheumatic agent (substance), Anti-rheumatic agent, Anti-rheumatic agent, NOS
Swedish Antireumatiska medel
Czech antirevmatika
Finnish Reumalääkkeet
Italian Farmaci antireumatici, Antireumatici
Russian PROTIVOVOSPALITEL'NYE SREDSTVA ZOLOTOSODERZHASHCHIE, PROTIVOREVMATICHESKIE SREDSTVA, ANTIREVMATICHESKIE SREDSTVA ZOLOTOSODERZHASHCHIE, BOLEZN'-SMIAGCHAIUSHCHIE ANTIREVMATICHESKIE LEKARSTVENNYE SREDSTVA, ANTIREVMATICHESKIE SREDSTVA, KHRIZOTERAPEVTICHESKIE SREDSTVA, ANTIREVMATICHESKIE LEKARSTVA, SMIAGCHAIUSHCHIE TECHENIE BOLEZNI, PROTIVOREVMATICHESKIE SREDSTVA ZOLOTOSODERZHASHCHIE, ZOLOTOSODERZHASHCHIE PROTIVOVOSPALITEL'NYE SREDSTVA, DMARD, АНТИРЕВМАТИЧЕСКИЕ ЛЕКАРСТВА, СМЯГЧАЮЩИЕ ТЕЧЕНИЕ БОЛЕЗНИ, АНТИРЕВМАТИЧЕСКИЕ СРЕДСТВА, БОЛЕЗНЬ-СМЯГЧАЮЩИЕ АНТИРЕВМАТИЧЕСКИЕ ЛЕКАРСТВЕННЫЕ СРЕДСТВА, ПРОТИВОРЕВМАТИЧЕСКИЕ СРЕДСТВА, АНТИРЕВМАТИЧЕСКИЕ СРЕДСТВА ЗОЛОТОСОДЕРЖАЩИЕ, ЗОЛОТОСОДЕРЖАЩИЕ ПРОТИВОВОСПАЛИТЕЛЬНЫЕ СРЕДСТВА, ПРОТИВОВОСПАЛИТЕЛЬНЫЕ СРЕДСТВА ЗОЛОТОСОДЕРЖАЩИЕ, ПРОТИВОРЕВМАТИЧЕСКИЕ СРЕДСТВА ЗОЛОТОСОДЕРЖАЩИЕ, ХРИЗОТЕРАПЕВТИЧЕСКИЕ СРЕДСТВА
Japanese 疾病-修飾抗リウマチ薬, 抗リウマチ剤, 疾病-修飾第二線薬, 抗リウマチ薬
Croatian Not Translated[Antirheumatic Agents]
Polish Leki przeciwreumatyczne, Leki przeciwreumatyczne modyfikujące chorobę, Leki zmieniające przebieg choroby
Spanish Antirreumáticos, Drogas Antirreumáticas Modificadoras de la Enfermedad, Agentes Antirreumáticos, agente antirreumático (producto), agente antirreumático (sustancia), agente antirreumático, antirreumático
Norwegian Antirevmatiske midler, DMARD, Antirevmatika
Portuguese Antirreumáticos, Drogas Modificadoras da Evolução de Doenças Reumáticas, Agentes Antirreumáticos
French Agents antirhumatismaux, Antirhumatismaux, Agent antirhumatismal, Antirhumatismal, Médicaments antirhumatismaux
German Antirheumatika, Rheumamittel
Derived from the NIH UMLS (Unified Medical Language System)

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