II. Definition

  1. Defective calcification of bone matrix in adults

III. Pathophysiology

  1. Defective bone calcification after Growth Plates close
  2. Associated with increased Osteoblast activity

V. Symptoms

  1. Anorexia and weight loss
  2. Muscle Weakness
  3. Bone pain

VI. Signs

  1. Skull, spine and Pelvis with deformities
  2. See Vitain D Deficiency

VII. Radiology

  1. Pseudofractures (Looser's Zones)
    1. Radiolucent defects of skull, spine and Pelvis
    2. Transverse lines in bony cortex
  2. Vertebral Fractures

VIII. Management

IX. References

  1. Drezner in Goldman (2004) Cecil Medicine, p. 1555-62
  2. Lane in Harris (2005) Kelly's Rheumatology, p. 1485-7

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Ontology: Osteomalacia (C0029442)

Definition (MSH) Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.
Definition (NCI_NCI-GLOSS) A condition in adults in which bones become soft and deformed because they don't have enough calcium and phosphorus. It is usually caused by not having enough vitamin D in the diet, not getting enough sunlight, or a problem with the way the body uses vitamin D. Symptoms include bone pain and muscle weakness. When the condition occurs in children, it is called rickets.
Definition (NCI) A metabolic bone disease that results from either a deficiency in vitamin D, or an abnormality in the metabolism of vitamin D, or a deficiency of calcium in the diet. The most common symptoms are bone pain and muscle weakness. When it occurs in children it is commonly referred to as rickets. (Diagnostic Surgical Pathology, 3rd ed.) --2003
Definition (CSP) inadequate or delayed mineralization of osteoid in mature cortical and spongy bone.
Concepts Disease or Syndrome (T047)
MSH D010018
ICD9 268.2
SnomedCT 190642003, 190639009, 154728003, 4598005
French OSTEOMALACIE, Rachitisme adulte, Ostéomalacie non précisée, Ostéomalacie
English OSTEOMALACIA, Osteomalacia unspecified, Osteomalacia, unspecified, osteomalacia, osteomalacia (diagnosis), Adult rickets, Osteomalacia NOS, Osteomalacia [Disease/Finding], adults rickets, adult rickets, Osteomalacia, Adult Rickets, Rickets, Adult, Osteomalacia unspecified (disorder), OM - Osteomalacia, Osteomalacia (disorder), malacia; bone
Portuguese OSTEOMALACIA, Raquitismo do adulto, Osteomalacia NE, Osteomalacia
Spanish OSTEOMALACIA, Osteomalacia no especificada, Raquitismo del adulto, osteomalacia no especificada, osteomalacia no especificada (trastorno), osteomalacia (trastorno), osteomalacia, Osteomalacia
German OSTEOMALAZIE, Osteomalazie, unspezifisch, Rachitis beim Erwachsenen, Osteomalazie
Dutch rachitis in volwassene, niet-gespecificeerde osteomalacie, malacie; bot, osteomalacie, Malacie, osteo-, Osteomalacie
Italian Rachitismo dell'adulto, Osteomalacia non specificata, Osteomalacia
Japanese 成人性くる病, 骨軟化症、詳細不明, 骨軟化症, セイジンセイクルビョウ, コツナンカショウ, コツナンカショウショウサイフメイ
Swedish Benvävsuppmjukning
Czech osteomalacie, Osteomalacie, Osteomalacie, blíže neurčená, Rachitida dospělých, měknutí kostí
Finnish Osteomalasia
Polish Osteomalacja
Hungarian Felnőttkori rachitis, Osteomalacia, Osteomalacia, nem meghatározott
Norwegian Osteomalasi, Osteomalaci