II. Epidemiology

  1. Accounts for one third of Nephrotic Syndrome in adults
  2. Accounts for >3% of new cases of End Stage Renal Disease
  3. Most common cause of idiopathic Nephrotic Syndrome in adults

III. Labs: Pathology with electron microscopy

  1. Sclerosis and hyalinosis of segments of <50% of all glomeruli

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Ontology: Focal glomerulosclerosis (C0017668)

Definition (NCI) A renal disorder characterized by sclerotic lesions in the glomeruli. Causes include drugs, viruses, and malignancies (lymphomas), or it may be idiopathic. It presents with asymptomatic proteinuria or nephritic syndrome and it may lead to renal failure.
Definition (MSH) A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
Concepts Disease or Syndrome (T047)
MSH D005923
SnomedCT 25821008, 236403004
English Focal Glomerulosclerosis, Focal Sclerosing Glomerulonephritides, Focal Sclerosing Glomerulonephritis, Glomerulonephritides, Focal Sclerosing, Glomerulonephritis, Focal Sclerosing, Sclerosing Glomerulonephritides, Focal, Sclerosing Glomerulonephritis, Focal, FSGS - Foc segment glomscleros, Focal segmental glomsclerosis, Glomerulosclerosis, Focal, Focal Segmental Glomerulosclerosis, Glomerulosclerosis, Focal Segmental, Segmental Glomerulosclerosis, Focal, FGS (focal glomerular sclerosis), Focal & segmental glomerulosclerosis, FSGS - Focal Segmental Glomerulosclerosis, Glomerulosclerosis, Focal Segmental [Disease/Finding], focal glomerulosclerosis, focal glomerular sclerosis, Focal and segmental glomerulosclerosis, focal segmental glomerulosclerosis (diagnosis), focal glomerulosclerosis (diagnosis), Focal segmental glomerulosclerosis (FSGS), Focal glomerular sclerosis, FGS - Focal glomerulosclerosis, FSGS - Focal segmental glomerulosclerosis, Focal segmental glomerulosclerosis, Focal glomerular sclerosis (disorder), Focal segmental glomerulosclerosis (disorder), Focal glomerulosclerosis, FSGS
Portuguese Glomerulosclerose Segmentar e Focal, Glomerulosclerose focal e segmentar, Glomerulosclerose focal, Glomerulesclerose Focal e Segmentar, Glomerulesclerose Segmentar e Focal, Glomerulosclerose Focal e Segmentar, Glomerulonefrite Esclerosante Focal
Spanish Glomeruloesclerosis Focal y Segmentaria, Glomeruloesclerosis focal y segmentaria, Glomerulosclerosis focal y segmentaria, Glomerulosclerosis focal, Glomerulosclerosis Focal y Segmentaria, Glomerulosclerosis Segmentaria y Focal, esclerosis glomerular focal (trastorno), esclerosis glomerular focal, glomeruloesclerosis focal, glomerulosclerosis segmentaria focal (trastorno), glomerulosclerosis segmentaria focal, Glomerulonefritis Esclerosante Focal
Italian Glomerulosclerosi focale segmentale, Glomerulosclerosi focale e segmentaria, Glomerulosclerosi segmentale focale, Glomerulosclerosi focale, Glomerulonefrite focale sclerosante
French Glomérulonéphrite focale, Glomérulonéphrite segmentaire et focale, Hyalinose segmentaire focale avec syndrome néphrotique, Hyalinose segmentaire et focale avec syndrome néphrotique, Glomérulosclérose focale
Swedish Fokal segmental glomeruloskleros
Dutch focale segmentale glomerulosclerose, focale en segmentale glomerulosclerose, focale glomerulosclerose
German fokale und segmentale Glomerulosklerose, fokal segmentale Glomerulosklerose, fokale Glomerulosklerose, Glomerulonephritis, fokale sklerosierende, Glomerulosklerose, fokale
Japanese ソウジョウブンセツセイシキュウタイコウカショウ, 糸球体腎炎-巣状硬化性, 巣状硬化性糸球体腎炎, 糸球体硬化症-巣状, 巣状糸球体硬化症, 腎糸球体硬化症-巣状, 分節性ヒアリン症, ヒアリン症-分節性, 巣状腎糸球体硬化症, ソウジョウシキュウタイコウカショウ, 糸球体硬化症-巣状分節性, 巣状分節性糸球体硬化症
Finnish Fokaalinen segmentaalinen glomeruloskleroosi
Czech glomeruloskleróza fokálně segmentová, glomeruloskleróza fokálně segmentární, glomeruloskleróza fokální, glomeruloskleróza fokálně segmentální, Fokální a segmentální glomerulonefritída, Fokální segmentová glomeruloskleróza, Fokální glomeruloskleróza
Polish Segmentalne szkliwiejące kłębuszkowe zapalenie nerek, Ogniskowe segmentalne szkliwienie kłębuszków nerkowych, Stwardnienie kłębuszków nerkowych ogniskowe segmentalne, Ogniskowe segmentalne stwardnienie kłębuszków nerkowych
Hungarian Focalis segmentalis glomerulosclerosis, Focalis és segmentalis glomerulosclerosis, focalis glomerulosclerosis
Norwegian Fokal segmental glomerulosklerose