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Ontology:
quazepam
(C0072828)
Definition (NCI)
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A synthetic benzodiazepine derivative with anxiolytic, sedative and hypnotic properties. Quazepam and its major metabolite 2-oxoquazepam potentiate gamma-aminobutyric acid (GABA) activity by binding to the benzodiazepine-1 recognition site (BZ-1) within the GABA-A receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of GABA-activated chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreased neuronal excitability.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C025130
|
SnomedCT |
108391004, 371372004 |
LNC |
LP17870-4, MTHU024725 |
English |
7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepine-2-thione, quazepam, 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-, quazepam (medication), quazepam [Chemical/Ingredient], QUAZEPAM, Quazepam (substance), Quazepam product (product), Quazepam product, Quazepam |
Spanish |
quazepam, producto (producto), quazepam (producto), quazepam, quazepam, producto, quazepam (sustancia), cuacepam (sustancia), cuazepam, cuacepam |
Ontology:
Doral
(C0720023)
Concepts |
Organic Chemical
(T109)
, Pharmacologic Substance
(T121)
|
MSH |
C025130
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English |
Doral, doral, Wallace brand of quazepam |