IV. Mechanism

  1. Strong Serotonin and Norepinephrine reuptake inhibitor
  2. Also with minor Dopamine reuptake inhibitor properties

V. Preparations

  1. Duloxetine Hydrochloride delayed release tablets (20g, 30 mg, 60 mg)

VI. Dosing

  1. Start: 20 mg twice daily or 30 mg daily
  2. Advance to 60 mg daily (or divided twice daily)

VII. Drug Interactions

  1. Monoamine Oxidase Inhibitors (MAO inhibitor)
    1. Do not use Duloxetine concurrently or within 14 days of last dose of MAO inhibitors
  2. Linezolid
  3. Methylene Blue

VIII. Safety

  1. Pregnancy Category: C
  2. Black box warning as for all Antidepressants for Suicidality in teens

X. References

  1. Jaouen and Lovecchio (2021) Crit Dec Emerg Med 31(12): 24

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Related Studies

Cost: Medications

duloxetine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
DULOXETINE HCL DR 20 MG CAP Generic $0.42 each
DULOXETINE HCL DR 30 MG CAP Generic $0.28 each
DULOXETINE HCL DR 40 MG CAP Generic $3.20 each
DULOXETINE HCL DR 60 MG CAP Generic $0.26 each
cymbalta (on 1/18/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
CYMBALTA 30 MG CAPSULE Generic $0.28 each
CYMBALTA 60 MG CAPSULE Generic $0.26 each

Ontology: duloxetine (C0245561)

Definition (NCI_NCI-GLOSS) A drug used to treat depression and peripheral neuropathy (pain, numbness, tingling, burning, or weakness in the hands or feet) that can occur with diabetes. It is also being studied in the treatment of peripheral neuropathy caused by certain anticancer drugs. Cymbalta increases the amount of certain chemicals in the brain that help relieve depression and pain. It is a type of serotonin and norepinephrine reuptake inhibitor.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C058218
SnomedCT 407033009, 407032004
LNC LP40294-8, MTHU021254
English N-methyl-3-(1-naphthalenyloxy)-2-thiophenepropanamine, N-methyl-3-(1-naphthalenyloxy)-3-(2-thiophene)propanamide, duloxetine, duloxetine [Chemical/Ingredient], DULoxetine, DULOXETINE, Duloxetine (product), Duloxetine (substance), Duloxetine
Spanish duloxetina (producto), duloxetina (sustancia), duloxetina

Ontology: Cymbalta (C1505021)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C058218
English Cymbalta, cymbalta, Eli Lilly brand of duloxetine hydrochloride