II. Indications
III. Contraindications
IV. Mechanism
- Strong Serotonin and Norepinephrine reuptake inhibitor
- Also with minor Dopamine reuptake inhibitor properties
V. Preparations
- Duloxetine Hydrochloride delayed release tablets (20g, 30 mg, 60 mg)
VI. Dosing
- Start: 20 mg twice daily or 30 mg daily
- Advance to 60 mg daily (or divided twice daily)
VII. Drug Interactions
-
Monoamine Oxidase Inhibitors (MAO inhibitor)
- Do not use Duloxetine concurrently or within 14 days of last dose of MAO inhibitors
- Linezolid
- Methylene Blue
VIII. Safety
- Pregnancy Category: C
- Black box warning as for all Antidepressants for Suicidality in teens
IX. Adverse Effects
- Nausea
- Xerostomia (Dry Mouth)
- Somnolence
- Constipation
- Decreased Appetite
- Hyperhidrosis
- Urinary Retention
X. References
- Jaouen and Lovecchio (2021) Crit Dec Emerg Med 31(12): 24
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Related Studies
| duloxetine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| DULOXETINE HCL DR 20 MG CAP | Generic | $0.42 each |
| DULOXETINE HCL DR 30 MG CAP | Generic | $0.28 each |
| DULOXETINE HCL DR 40 MG CAP | Generic | $3.20 each |
| DULOXETINE HCL DR 60 MG CAP | Generic | $0.26 each |
| cymbalta (on 1/18/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CYMBALTA 30 MG CAPSULE | Generic | $0.28 each |
| CYMBALTA 60 MG CAPSULE | Generic | $0.26 each |
Ontology: duloxetine (C0245561)
| Definition (NCI_NCI-GLOSS) | A drug used to treat depression and peripheral neuropathy (pain, numbness, tingling, burning, or weakness in the hands or feet) that can occur with diabetes. It is also being studied in the treatment of peripheral neuropathy caused by certain anticancer drugs. Cymbalta increases the amount of certain chemicals in the brain that help relieve depression and pain. It is a type of serotonin and norepinephrine reuptake inhibitor. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C058218 |
| SnomedCT | 407033009, 407032004 |
| LNC | LP40294-8, MTHU021254 |
| English | N-methyl-3-(1-naphthalenyloxy)-2-thiophenepropanamine, N-methyl-3-(1-naphthalenyloxy)-3-(2-thiophene)propanamide, duloxetine, duloxetine [Chemical/Ingredient], DULoxetine, DULOXETINE, Duloxetine (product), Duloxetine (substance), Duloxetine |
| Spanish | duloxetina (producto), duloxetina (sustancia), duloxetina |
Ontology: Cymbalta (C1505021)
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | C058218 |
| English | Cymbalta, cymbalta, Eli Lilly brand of duloxetine hydrochloride |
