Methylphenidate

Aka: Methylphenidate, Ritalin, Methylin, Concerta

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II. Indications: Methylphenidate (Ritalin)

  1. Attention Deficit Hyperactivity Disorder (ADHD)
  2. Narcolepsy
  3. Depression in medically ill elderly patients
  4. Enhanced pain control in patients on Opiates

III. Contraindications

  1. See Drug Interactions below
  2. Congenital Heart Defect (ask related PMH, Family History and screen on ADHD exam)
    1. Consider an EKG before prescribing
    2. Vetter (2008) Circulation 117(18):2407-23. [PubMed]
  3. Motor Tics or Tourette's Syndrome
  4. Glaucoma
  5. Seizure disorder
  6. Hypertension
  7. Pregnancy

IV. Pharmacokinetics: Methylphenidate

  1. Immediate Release: Ritalin-IR, Methylin IR
    1. Onset of action: within 20 to 30 minutes of dose (up to 60 minutes)
    2. Peaks at 1.9 hours on average
    3. Duration: 3 to 6 hours
  2. Immediate Release: Focalin (Dexmethylphenidate)
    1. D-isomer of Ritalin (l-isomer is inactive)
    2. Prescribed at half dose of Ritalin
    3. Same pharmacokinetics as immediate release Methylphenidate
    4. Fewer Headaches but more Stomache pain than with Methylphenidate
  3. Long-Acting: Ritalin-LA
    1. Duration: 8 hours
    2. Biphasic release
      1. Immediate release: 50%
      2. Modified release beads: 50%
    3. Preferred over Ritalin SR
  4. Long-Acting: Ritalin-SR, Metadate ER, Methylin ER
    1. Onset of action: within 90 minutes of dose
    2. Peaks at 3 hours on average
    3. Duration: 5-8 hours (gradual decrease after 3 hours)
    4. Less effective than Ritalin IR bid
    5. Other sustained release forms are preferred
  5. Very-Long-Acting: Concerta
    1. Onset of action: within 60 to 120 minutes of dose
    2. Duration: 12 hours
    3. Comparable to Ritalin-IR tid
  6. Very-Long-Acting: Metadate-CD
    1. Flat concentration curve despite biphasic release
    2. Duration: 8-10 hours
    3. Biphasic peaks at 1.5 hours and again at 4.5 hours
      1. Immediate release beads: 30%
      2. Extended release beads: 70%
  7. Very-Long Acting: Quillivant XR
    1. Combination of Immediate release Methylphenidate (20%) and extended release Methylphenidate (80%)
    2. Peaks at 5 hours
    3. Duration: 12 hours
    4. Niche is that it is suspension (compounded by pharmacy) at 5 mg/ml
      1. Other stimulant capsules can be sprinkled on apple sauce (Focalin XR, Metadate CD, Ritalin LA, Adderall XR)
    5. References
      1. (2013) Presc Lett 20(2): 8-9

V. Dosing: Children (over age 6 years)

  1. Maximum total daily dose: 60 mg/day
  2. Immediate Release: Methylphenidate
    1. Usual Range: 0.5 - 1 mg/kg/day
    2. Start: 2.5 to 5 mg per dose, twice daily
    3. Initial Schedule (lasts 4 hours - dose up to 4 times daily)
      1. Morning: 2.5 to 5 mg PO 30 minutes before breakfast
      2. Noon: 2.5 to 5 mg PO 30 minutes before lunch
      3. Afternoon: 1.25 to 2.5 mg PO at 3-4 pm
    4. Titrate dose up weekly
      1. Increase dose by 0.1 mg/kg/dose (or 5-10 mg/day)
    5. Maximum dose: 2 mg/kg/day or 60 mg/day (some sources suggest maximum up to 90)
  3. Immediate Release: Focalin (Dexmethylphenidate)
    1. Start: 2.5 mg orally twice daily
    2. Usual Dose: 5-10 mg orally twice daily
    3. Maximum Dose: 20 mg orally daily
  4. Sustained Release
    1. Concerta 18 to 54 mg orally daily
      1. Start: 18 mg qAM
      2. May increase weekly by 18 mg/day
      3. Conversions
        1. Ritalin 5 mg or 20 mg SR: Concerta 18 mg
        2. Ritalin 10 mg or 40 mg SR: Concerta 36 mg
        3. Ritalin 15 mg or 60 mg SR: Concerta 54 mg
      4. Maximum: 72 mg/day
    2. Ritalin LA or Metadate CD
      1. Start: 20 mg orally daily
      2. May increase weekly by 10-20 mg/day
      3. Usual dose: 20-40 mg orally once daily
      4. Maximum: 60 mg/day
    3. Ritalin-SR (Other long-acting agents are preferred)
      1. Dose: 0.6 to 2 mg/kg up to 20-40 mg orally daily
      2. Dose is directly converted from Regular Ritalin
      3. Conversion to Ritalin SR (Metadate ER, Methylin ER)
      4. Administer cumulative 8 hour regular dose
      5. Example: Conversion
        1. Child takes Ritalin 10 mg, 5 mg, and 5 mg
        2. Ritalin SR dosing will be 20 mg qAM
      6. Example: Schedule
        1. Morning: 20-40 mg orally
        2. Early afternoon: 20 mg orally
    4. Daytrana (Methylphenidate patch)
      1. Start: 10 mg patch worn 9 hours daily
      2. Max: 30 mg patch worn 9 hours daily
      3. Skin irritation or rash may occur

VI. Dosing: Adults with ADHD or Narcolepsy

  1. Maximum total daily dose: 90 mg
  2. Regular Release: 5 to 20 mg PO bid to tid at meals
  3. Sustained Release: 20 mg PO up to q8 hours

VII. Dosing: Elderly with comorbid Depression

  1. Maximum total daily dose: 30 mg
  2. Regular Release: 5 to 10 mg bid to tid

VIII. Precautions: Maximum Dosing

  1. Adults and older adolescents (>50 kg) may in some cases need dosing in excess of listed maximum
  2. Exercise caution and Informed Consent as these doses are not FDA approved and exceed the manufacturers recommendation
  3. Absolute maximum doses
    1. Methylphenidate: 100 mg per day in divided doses
    2. Concerta 108 mg per day
  4. (2013) Presc Lett 20(9): 50-1

IX. Drug Interactions

  1. Avoid concurrent Decongestant use
  2. Avoid within 14 days of MAO inhibitor

X. Monitoring: Each Visit

  1. Height
  2. Weight
  3. Blood Pressure
  4. Pulse

XI. Adverse Effects

  1. See ADHD Medication

XII. References

  1. (2002) Lexicomp Drug Database
  2. (1996) Pediatrics 98:301-4 [PubMed]
  3. Andesman (1999) Pediatr Clin North Am 46:945-63 [PubMed]
  4. Bennett (1999) Pediatr Clin North Am 46:929-44 [PubMed]
  5. Challman (2000) Mayo Clin Proc 75:711-21 [PubMed]
  6. Pliszka (2007) J Am Acad Child Adolesc Psychiatry 46(7):894-921 [PubMed]
    1. http://www.jaacap.com/article/S0890-8567(09)62182-1/fulltext

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Related Studies

Cost: Medications

methylphenidate (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
METHYLPHENIDATE 10 MG TABLET Generic $0.54 each
METHYLPHENIDATE 10 MG/5 ML SOL Generic $0.91 per ml
METHYLPHENIDATE 20 MG TABLET Generic $0.77 each
METHYLPHENIDATE 5 MG TABLET Generic $0.42 each
METHYLPHENIDATE 5 MG/5 ML SOLN Generic $0.66 per ml
METHYLPHENIDATE CD 10 MG CAP Generic $2.96 each
METHYLPHENIDATE CD 20 MG CAP Generic $3.30 each
METHYLPHENIDATE CD 30 MG CAP Generic $3.16 each
METHYLPHENIDATE CD 40 MG CAP Generic $4.20 each
METHYLPHENIDATE CD 50 MG CAP Generic $4.67 each
METHYLPHENIDATE CD 60 MG CAP Generic $5.36 each
METHYLPHENIDATE ER 10 MG CAP Generic $2.96 each
METHYLPHENIDATE ER 10 MG TAB Generic $4.48 each
METHYLPHENIDATE ER 18 MG TAB Generic $6.91 each
METHYLPHENIDATE ER 20 MG CAP Generic $4.38 each
METHYLPHENIDATE ER 20 MG TAB Generic $3.71 each
METHYLPHENIDATE ER 27 MG TAB Generic $3.92 each
METHYLPHENIDATE ER 30 MG CAP Generic $4.12 each
METHYLPHENIDATE ER 36 MG TAB Generic $7.37 each
METHYLPHENIDATE ER 40 MG CAP Generic $4.30 each
METHYLPHENIDATE ER 50 MG CAP Generic $4.67 each
METHYLPHENIDATE ER 54 MG TAB Generic $4.29 each
METHYLPHENIDATE ER 60 MG CAP Generic $5.36 each
METHYLPHENIDATE LA 20 MG CAP Generic $4.38 each
METHYLPHENIDATE LA 30 MG CAP Generic $4.12 each
METHYLPHENIDATE LA 40 MG CAP Generic $4.30 each
ritalin (on 1/4/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
RITALIN 10 MG TABLET Generic $0.54 each
RITALIN 20 MG TABLET Generic $0.77 each
RITALIN LA 10 MG CAPSULE $8.78 each
RITALIN LA 20 MG CAPSULE Generic $4.38 each
RITALIN LA 30 MG CAPSULE Generic $4.12 each
RITALIN LA 40 MG CAPSULE Generic $4.30 each
methylin (on 2/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
METHYLIN 5 MG/5 ML SOLUTION Generic $0.66 per ml
concerta (on 3/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
CONCERTA ER 18 MG TABLET $9.57 each
CONCERTA ER 27 MG TABLET $9.82 each
CONCERTA ER 36 MG TABLET $10.21 each
CONCERTA ER 54 MG TABLET $10.97 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ontology: Methylphenidate (C0025810)

Definition (CHV) a drug that stimulates the brain
Definition (MSH) A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE.
Definition (NCI) A synthetic central nervous system stimulant. Methylphenidate appears to activate the brain stem arousal system and cortex to produce its stimulant effect and, in some clinical settings, may improve cognitive function.
Definition (CSP) central stimulant used in treatment of hyperkinetic children, various types of depression, and narcolepsy.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008774
SnomedCT 18548003, 373337007
LNC LP16202-1, MTHU008754
English Methylphenidate, 2-Piperidineacetic acid, alpha-phenyl-, methyl ester, alpha-Phenyl-2-piperidineacetic Acid Methyl Ester, methylphenidate, METHYLPHENIDATE, Methylphenidate [Chemical/Ingredient], Methylphenidate (product), Methylphenidate (substance), d-methylphenidate
Swedish Metylfenidat
Czech methylfenidát
Finnish Metyylifenidaatti
Russian METILFENIDAT, FENIDILAT, МЕТИЛФЕНИДАТ, ФЕНИДИЛАТ
Japanese フェニジレート, リタリン, 塩酸メチルフェニデート, メチルフェニデート
Polish Rytalin, Metylofenidat
Spanish Ritalin, metilfenidato (producto), metilfenidato (sustancia), metilfenidato, Metilfenidato
Portuguese Ritalin, Metilfenidato
French Méthylphénidate
German Methylphenidat
Italian Metilfenidato
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Ritalin (C0728759)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008774
German Ritalin
English Ritalin, Cephalon Brand of Methylphenidate Hydrochloride, Novartis Brand 1 of Methylphenidate Hydrochloride, Ritaline
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Methylin (C0876085)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008774
English methylin, Methylin, Mallinckrodt Brand of Methylphenidate Hydrochloride
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Concerta (C0939301)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008774
English concerta, Concerta
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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