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Ontology:
Midodrine
(C0026078)
|
Definition (MSH)
|
An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
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|
Definition (NCI)
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A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS).
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D008879
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| SnomedCT |
108539003, 372504000 |
| English |
Midodrin, Midodrine, Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-, Midodrine [Chemical/Ingredient], midodrin, midodrine, MIDODRINE, Midodrine (product), Midodrine (substance) |
| Swedish |
Midodrin
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| Czech |
midodrin
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| Finnish |
Midodriini
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| Russian |
MIDODRIN, МИДОДРИН |
| Japanese |
ミドドリン
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| Polish |
Midodrin
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| Spanish |
midodrina (producto), midodrina (sustancia), midodrina, Midodrina |
| French |
Midodrine
|
| German |
Midrodin
|
| Italian |
Midodrina
|
| Portuguese |
Midodrina
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