II. Indications

III. Mechanism

  1. Alpha Agonist: constricts arterioles and veins
  2. Increases peripheral resistance

IV. Efficacy

  1. Study: n=162, PCT
    1. Significantly improved standing BP and symptoms
  2. Reference
    1. Low (1997) JAMA 277:1046-51 [PubMed]

V. Adverse Effects

  1. Pilomotor reactions
  2. Urinary urgency and retention
  3. Supine Hypertension

VI. Dosing

  1. Dose: 10 mg PO tid

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Related Studies

Cost: Medications

midodrine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
MIDODRINE HCL 10 MG TABLET Generic $0.85 each
MIDODRINE HCL 2.5 MG TABLET Generic $0.36 each
MIDODRINE HCL 5 MG TABLET Generic $0.53 each

Ontology: Midodrine (C0026078)

Definition (MSH) An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
Definition (NCI) A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS).
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008879
SnomedCT 108539003, 372504000
English Midodrin, Midodrine, Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-, Midodrine [Chemical/Ingredient], midodrin, midodrine, MIDODRINE, Midodrine (product), Midodrine (substance)
Swedish Midodrin
Czech midodrin
Finnish Midodriini
Japanese ミドドリン
Polish Midodrin
Spanish midodrina (producto), midodrina (sustancia), midodrina, Midodrina
French Midodrine
German Midrodin
Italian Midodrina
Portuguese Midodrina