III. Dosing

  1. Sublingual
    1. One tab SL
    2. Repeat in 1/2 hour prn
    3. Maximum: 3/day or 6/week
    4. Oral tablets available
  2. Rectal Suppository (Wigraine)
    1. One rectally at Headache onset
    2. May repeat hourly
    3. Maximum: 2 suppositories per day or 12 per month
    4. Limit no more than 2 days per week
    5. May use for Menstrual Migraine

IV. Adverse Effects

  1. Nausea, Vomiting
    1. Use Antiemetic
  2. Rebound Headache
  3. Occluded vessel in Overdose
    1. Overdose levels
      1. Daily use exceeds 6 mg
      2. Weekly use exceeds 10 mg
    2. Potentiated by
      1. Beta Blockers
      2. Dopamine
      3. Fever
      4. Liver Disease

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Related Studies

Ontology: Ergotamine (C0014710)

Definition (MSH) A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.
Definition (NCI) A naturally occurring ergot alkaloid with vasoconstrictor and analgesic property. Ergotamine selectively binds and activates serotonin (5-HT) 1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, thereby resulting in vasoconstriction and reducing the blood flow in cerebral arteries that may lead to relieve of vascular headaches. This agent also selectively binds to alpha-adrenergic receptors, thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins, which also contributes to the relief of headaches. Furthermore, the activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004878
SnomedCT 363568006, 32647002, 395975005
LNC LP17994-2, MTHU024862
English Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, ergotamines (medication), ergotamines, Ergotamine [Chemical/Ingredient], Ergotamine, Ergotamine product, Ergotamine product (product), ergotamine, ERGOTAMINE, Ergotamine (product), Ergotamine (substance), Ergotamine product (substance)
Swedish Ergotamin
Czech ergotamin
Finnish Ergotamiini
Japanese エルゴタミン, カフェルゴット, 酒石酸エルゴタミン, 酒石酸エルゴタミン・無水カフェイン, ヘクト・M
Polish Ergotamina
Spanish ergotamina, producto (producto), ergotamina, producto, ergotamina (producto), ergotamina (sustancia), ergotamina, Ergotamina
French Ergotamine
German Ergotamin
Italian Ergotammina
Portuguese Ergotamina

Ontology: Wigraine (C0724401)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Wigraine, wigraine