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Ontology:
Ergotamine
(C0014710)
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Definition (MSH)
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A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.
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Definition (NCI)
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A naturally occurring ergot alkaloid with vasoconstrictor and analgesic property. Ergotamine selectively binds and activates serotonin (5-HT) 1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, thereby resulting in vasoconstriction and reducing the blood flow in cerebral arteries that may lead to relieve of vascular headaches. This agent also selectively binds to alpha-adrenergic receptors, thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins, which also contributes to the relief of headaches. Furthermore, the activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D004878
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| SnomedCT |
363568006, 32647002, 395975005 |
| LNC |
LP17994-2, MTHU024862 |
| English |
Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, ergotamines (medication), ergotamines, Ergotamine [Chemical/Ingredient], Ergotamine, Ergotamine product, Ergotamine product (product), ergotamine, ERGOTAMINE, Ergotamine (product), Ergotamine (substance), Ergotamine product (substance) |
| Swedish |
Ergotamin
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| Czech |
ergotamin
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| Finnish |
Ergotamiini
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| Russian |
ERGOTAMIN, ЭРГОТАМИН |
| Japanese |
エルゴタミン, カフェルゴット, 酒石酸エルゴタミン, 酒石酸エルゴタミン･無水カフェイン, ヘクト･M |
| Croatian |
ERGOTAMIN
|
| Polish |
Ergotamina
|
| Spanish |
ergotamina, producto (producto), ergotamina, producto, ergotamina (producto), ergotamina (sustancia), ergotamina, Ergotamina |
| French |
Ergotamine
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| German |
Ergotamin
|
| Italian |
Ergotammina
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| Portuguese |
Ergotamina
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Ontology:
Wigraine
(C0724401)
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
| English |
Wigraine, wigraine |
