Images: Related links to external sites (from Bing)
Ontology:
Ergotamine
(C0014710)
Definition (MSH)
|
A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.
|
Definition (NCI)
|
A naturally occurring ergot alkaloid with vasoconstrictor and analgesic property. Ergotamine selectively binds and activates serotonin (5-HT) 1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, thereby resulting in vasoconstriction and reducing the blood flow in cerebral arteries that may lead to relieve of vascular headaches. This agent also selectively binds to alpha-adrenergic receptors, thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins, which also contributes to the relief of headaches. Furthermore, the activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
|
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D004878
|
SnomedCT |
363568006, 32647002, 395975005 |
LNC |
LP17994-2, MTHU024862 |
English |
Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, ergotamines (medication), ergotamines, Ergotamine [Chemical/Ingredient], Ergotamine, Ergotamine product, Ergotamine product (product), ergotamine, ERGOTAMINE, Ergotamine (product), Ergotamine (substance), Ergotamine product (substance) |
Swedish |
Ergotamin
|
Czech |
ergotamin
|
Finnish |
Ergotamiini
|
Russian |
ERGOTAMIN, ЭРГОТАМИН |
Japanese |
エルゴタミン, カフェルゴット, 酒石酸エルゴタミン, 酒石酸エルゴタミン・無水カフェイン, ヘクト・M |
Croatian |
ERGOTAMIN
|
Polish |
Ergotamina
|
Spanish |
ergotamina, producto (producto), ergotamina, producto, ergotamina (producto), ergotamina (sustancia), ergotamina, Ergotamina |
French |
Ergotamine
|
German |
Ergotamin
|
Italian |
Ergotammina
|
Portuguese |
Ergotamina
|
Ontology:
Wigraine
(C0724401)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
English |
Wigraine, wigraine |