Lab

Urine Ketone

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Urine Ketone

  • Mechanism
  1. Dipstick detects acetic acid (Acetoacetate)
    1. In Diabetic Ketoacidosis, Beta-Hydroxybutyrate (primary Ketone) is converted to Acetoacetate
  2. Confirmatory Test
    1. Urine
      1. Acetest tablet test
    2. Blood (preferred)
      1. Beta-Hydroxybutyrate
        1. Best Ketone test
      2. Basic chemistry panel
        1. Ketoacidosis
          1. Low serum bicarbonate
          2. Increased Anion Gap
        2. Normal or resolving Ketoacidosis
          1. Normal serum bicarbonate
          2. Normal Anion Gap
  • Interpretation
  • Normal
  1. Negative
  • Causes
  • Positive
  1. Dehydration
  2. Starvation or Low Carbohydrate Diets
  3. Diabetic Ketoacidosis (DKA)
  4. Alcoholic Ketoacidosis
  5. Isopropanol toxicity
  6. Pregnancy
  1. Low Urine pH (acidic)
  2. Increased Urine Specific Gravity
  3. Phenolphthalein
  4. Levodopa
  1. Delayed urine exam