Lab

Sulfosalicylic Acid Test

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Sulfosalicylic Acid Test, Protein Precipitation Test

  • Indication
  1. Confirmation of proteiunuria on Urine Protein dipstick
  2. Replaced with Urine Protein to Creatinine Ratio
  • Efficacy
  1. Highly sensitive for Urine Protein
  2. Detects light chain proteins
  • Technique
  1. Urine mixed with 20% Sulfosalicylic Acid (SSA)
  2. Variation in results may be as much as 20%
  3. Urine turbidity measured with photometer (increased turbidity with precipitated protein)
    1. Turbidity reported as trace to 4+
  • Interpretation
  • Positive Test
  1. Radiographic contrast agents (in last 3 days)
  2. Tolbutamide
  3. Penicillins
  4. Sulfisoxazole
  • Interpretation
  • Negative Test
  1. False Proteinuria
  2. Renal Tubules not reabsorbing