Pharm
Risperidone
search
Risperidone
, Risperdal
See Also
Antipsychotic Medication
Psychosis
Class
Atypical Antipsychotic
(Second
Gene
ration agent)
Neuroleptic
Adverse Effects
Insomnia
Hypotension
Weight gain
Extrapyramidal Side Effect
s
Low risk when daily dose under 10 mg
Peristent
Tardive Dyskinesia
Lower
Incidence
than with other
Neuroleptic
s
Exacerbates
Parkinson's Disease
movement
Dosing
Initial
Adult: 1 mg PO bid
Elderly: 0.25 mg qd to 0.5 mg PO bid
Slow titration to average dosing
Adult: 2 to 4 mg PO daily (or divided bid)
Elderly with
Dementia
: 0.5 to 0.75 mg PO bid
Maximum: 16 mg/day
Monitoring
See
Antipsychotic
s
Consider EKG,
Electrolyte
and
Magnesium
monitoring due to
QT Interval
prolongation risk
Drug Interactions
Metabolized by
Cytochrome P450
2D6
Increase
Antipsychotic
levels (toxicity risk): Monitor for toxicity
Clozapine
Fluoxetine
Paroxetine
Decrease
Antipsychotic
levels (lower efficacy)
Barbiturate
s
Carbamazepine
Phenytoin
Rifampin
Other effects
Increased antihypertensive effect (may result in
Hypotension
)
Raises
Prolactin
levels
Avoid concurrent use of other medications prolonging
QT Interval
See
Prolonged QT Interval due to Medication
References
Jeste (2000) Am J Psychiatry 157:1150-5 [PubMed]
Motsinger (2003) Am Fam Physician 67(11):2335-40 [PubMed]
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