Analgesic
Morphine Sulfate
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Morphine Sulfate
, Morphine
See Also
Opioid
Bowel Regimen in Chronic Narcotic Use
Narcotic Overdose
Dosing
Analgesia
Child
Dose: 0.025-0.1 mg/kg IV/IM/SQ q3-4h
Adult
Intravenous: 1-4 mg (0.1-0.2 mg/kg)
Other routes: 10-20 mg (up to 30 mg) every 4 hours IM, PO or PR
Morphine immediate release 15 mg PO is equivalent to 5 mg IV
Morphine immediate release is available in 15 mg and 30 mg tablets
Morphine is less euphoric than
Oxycodone
and
Hydrocodone
Dosing
Procedural Sedation and Analgesia
IV/IM/SC: 0.05 to 0.2 mg/kg every 2-4 hours up to 15 mg (typically given in 2-4 mg increments)
Intramuscular onset of activity may be delayed as long as 30 minutes
Adverse Effects
See
Opioid Adverse Effect
Histamine release (more than with other
Opioid Analgesic
s)
Pruritus
and/or rash are common
Typically not
Allergic Reaction
Nausea
or
Vomiting
Consider pretreatment with
Antiemetic
(e.g.
Ondansetron
)
Hypotension
Consider pretreatment bolus of crystalloid (500 cc or 10-20 cc/kg NS)
Oversedation
Reversal:
Naloxone
References
Acker, Koval and Leeper (2017) Crit Dec Emerg Med 31(4): 3-13
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