Pharm

Lamotrigine

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Lamotrigine, Lamictal

  • Adverse Effects
  • Dose related
  • Dosing
  • Adults
  1. Initial: 25 mg every other day for 2 weeks
  2. Next: 25 mg orally daily for 2 weeks
  3. Target dose: 50-100 mg orally twice daily
  4. Maximum dose: 400 mg/day
  5. Precautions
    1. Slow titration over 6 weeks or more reduces the risk of Stevens-Johnson Syndrome
    2. Dosing adjustments are needed when used with agents listed under Drug Interactions
  • Monitoring
  1. Obtain labs monthly for the first 2 months and then every 3 to 12 months
  2. Complete Blood Count
  3. Liver Function Test