Anatomy
Serotonin
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Serotonin
, Serotoninergic, 5-Hydroxytryptamine, 5-HT
See Also
Serotonin Syndrome
Carcinoid Syndrome
Physiology
Neurotransmitter
Motor control
Pain
Perception
Sympathetic Nervous System
outflow
Synthesis from essential amino acid L-tryptophan
Serotonin Receptors
Serotonin-1 Receptor (5-HT-1) Activity
Anti-depressant effect
Serotonin-2 Receptor (5-HT-2) Activity
Inhibits 5-HT-1 Receptor
Causes
Sexual Dysfunction
Causes
Insomnia
Causes anxiety
Serotonin-3 Receptor (5-HT-3) Activity
Causes Gastrointestinal symptoms
Causes
Headache
Medications
Increase Serotonin levels
Increased Serotonin synthesis: L-Tryptophan
Decrease Serotonin metabolism:
MAO inhibitor
s
Increase Serotonin release:
Amphetamine
s,
Cocaine
Inhibit Serotonin uptake
Tricyclic Antidepressant
s:
Amitriptyline
Selective Serotonin Reuptake Inhibitor
(
SSRI
):
Prozac
Other:
Meperidine
,
Dextromethorphan
Direct Serotonin Receptor Agonists:
Buspar
,
Imitrex
Dopamine Agonist
s:
Amantadine
,
Wellbutrin
,
Levodopa
Other Non-specific Serotonin increase:
Lithium
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