Extrinsic Asthma


Extrinsic Asthma, Allergic Asthma, T2 Asthma, T2 High Asthma, Th2 Asthma, Type 2 Asthma, Atopic Asthma, Eosinophilic Asthma

  • Epidemiology
  1. Much more common in children than adults
  2. Age Onset under 40 years old
  • Pathophysiology
  1. IgE mediated response to allergens
    1. Immediate Allergic Reaction
    2. Late-phase Allergic Reaction
  • Causes
  1. Indoor allergens (perennial allergens)
    1. House Dust mites (most common extrinsic allergen)
    2. Animal Proteins (cat or dog dander)
    3. Mold spores (e.g. Alternaria)
    4. Cockroaches (esp. German Cockroach)
  2. Outdoor allergens (seasonal allergens)
    1. Tree, grass or weed pollens
    2. Mold Spores
  3. Samter's Triad
    1. Aspirin or NSAID sensitivity
    2. Nasal Polyps
    3. Asthma
  • Symptoms
  • Management
  1. See Environmental Allergen
  2. See Asthma Management
  3. See Asthma Exacerbation
  4. Consider Immunotherapy for those with persistent Allergic Rhinitis and Asthma
  5. Allergic, refractory Severe Asthma may be treated with biologic agents