Pharm

Third Generation Anti-Pseudomonal Cephalosporins

search

Third Generation Anti-Pseudomonal Cephalosporins, Ceftazidime, Fortaz, Ceftazidime-Avibactam, Zavicefta

  • Indications
  • Conditions
  1. Gram-Negative, Multi-drug resistant intraabdominal Infections and Urinary Tract Infections
  • Pharmacokinetics
  1. Half-Life Ceftazidime: 2.7 (similar for Avibactam)
  2. Ceftazidime is excreted in urine (80-90% unchanged)
  3. Adjust dose in Renal Failure
  • Preparations
  1. Ceftazidime (Fortaz)
    1. Adult: 1-2 grams IM or IV every 8 to 12 hours
    2. Child: 30-50 mg/kg IV every 8 hours
  2. Ceftazidime-Avibactam (Zavicefta)
    1. Addition of Beta-Lactamase inhibitor (Avibactam) circumvents Beta-Lactamase resistance
    2. Ceftazidime-Avibactam (2g-0.5g) 62.5 g IV every 8 hours for 7-14 days
    3. Combined with Metronidazole for intraabdominal infections
  • Precautions
  1. Avoid Avibactam in pregnancy (adverse effects in pregnancy)
  • Disadvantages
  1. Most expensive
  2. Limited spectrum
  • Adverse Effects
  • References
  1. Morrison and LoVecchio (2021) Crit Dec Emerg Med 35(1): 28