Pharm

Quinupristin-Dalfopristin

search

Quinupristin-Dalfopristin, Synercid, Streptogramin

  • Mechanism
  1. Bacterial 50S Ribosome
  2. Resistance rare
  • Pharmacokinetics
  1. Hepatic clearance predominates
  2. Half-life: 1-3 hours (9-10 hours of affect)
  • Adverse Effects
  1. Arthralgias or myalgias
  2. Nausea, Diarrhea or Vomiting
  3. Rash or Pruritus
  4. Headache
  1. Raises serum drug levels of substrates in 3A4 system
  2. Follow Cyclosporine levels when using concurrently
  • Dosing
  1. Enterococcus faecium: 7.5 mg/kg IV q8 hours
  2. Severe Skin Infections: 7.5 mg/kg IV q12 hours