Pharm

Chloroquine

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Chloroquine, Aralen

  • Indications
  1. Malaria Prophylaxis
    1. Areas without Chloroquine resistance
  2. Discoid Lupus (off label)
  3. NOT indicated in COVID-19 outside of clinical trials as of May 2020
    1. Low efficacy in trials to date and risk of serious reactions (including QTc Prolongation)
    2. https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v2
  • Safety
  1. Safe in all trimesters of pregnancy (but Chloroquine does cross the placenta)
  2. Safe for children of all ages
  • Dose
  • Prophylaxis
  1. Protocol
    1. Start 1-2 weeks before travel
    2. Continue through 4 weeks after return
  2. Adult: 300 mg base (500 mg salt) PO once weekly
  3. Child: Dose: 5 mg/kg base (8.3 mg/kg salt) up to 300 mg base orally once weekly
  • Directions
  1. Taking with food decreases gastric irritation
  • Efficacy
  1. Most world regions exhibit high Chloroquine resistance in Plasmodium Falciparum
  • References
  1. (2020) LexiComp, Chloroquine, accessed 5/6/2020