Platelet

Platelet Dysfunction

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Platelet Dysfunction, Platelet Bleeding Disorder, Thrombasthenia

  • Causes
  • Congenital Platelet Dysfunction
  1. Von Willebrand's Disease
  2. Glanzmann's Thrombasthenia (Autosomal Recessive)
    1. Platelet membrane deficiency Glycoprotein IIb, IIIa
    2. Defective binding of platelet Fibrinogen
    3. Decreased platelet aggregation
  3. Bernard-Soulier Disease (Autosomal Recessive)
    1. Platelet membrane deficiency Glycoprotein Ib
    2. Coagulation Factor X and Factor V deficiency
    3. Large platelets and decreased platelet aggregation
  4. Storage Pool Disease
    1. Dense granule and/or alpha granule deficiency
    2. Defective platelet release of ADP and Serotonin