Pharm

Medication Causes of Neutropenia

search

Medication Causes of Neutropenia, Neutropenia due to Medication, Drug-Induced Neutropenia, Drug-Induced Agranulocytosis

  • Pathophysiology
  1. Drugs are second most common cause of Neutropenia
  2. Induce hypoproliferation via marrow injury
  • Causes
  • Most common
  1. Chemotherapeutics (standard effect, see below)
  2. Thyroid inhibitors (Antithyroid Drugs)
  3. Trimethoprim-Sulfamethoxazole (Septra, Bactrim)
  4. Sulfasalazine
  5. Clomipramine
  6. Dipyrone
  7. Concurrent Analgesic use is predisposing factor
  • Causes
  • Chemotherapeutics (most common causes)
  1. See Alkylating Agents
  2. See Antimetabolite Chemotherapy
  3. Anthracyclines (e.g. Doxorubicin, Daunorubicin)
  4. Taxanes (e.g. Paclitaxel, Docetaxel)
  5. Topoisomerase inhibitors (Etoposide)
  6. Platinum Chemotherapy (e.g. Cisplatin)
  7. Gemcitabine (Gemzar)
  8. Vinorelbine (Navelbine)
  9. [PubMed]
  • Causes
  • Neuropsychotropics
  1. Phenothiazine (e.g. chlorpromazine)
  2. Meprobamate
  3. Barbiturates
  4. Clozapine (Clozaril)
  5. Risperidone (Risperdal)
  6. Imipramine or Desipramine
  7. Thiothixene (Navane)
  8. Haloperidol (Haldol)
  9. Valproic Acid (Depakote)
  10. Phenytoin (Dilantin)
  11. Carbamazepine (Tegretol)
  12. Ethosuximide (Zarontin)
  • Causes
  • Miscellaneous
  1. Allopurinol
  2. Colchicine
  3. Antithyroid Drugs (e.g. Propylthiouracil)
  4. Antihistamines (e.g. Cimetidine, Brompheniramine)
  5. Quinine
  6. Heavy Metals
    1. Gold
    2. Arsenic
    3. Mercury
  • References
  1. Lee (1999) Wintrobe's Hematology, Lippincott, p. 1862-9
  2. van der Klauw (1999) Arch Intern Med 159(4):369-74 [PubMed]