Pharm
Blood Transfusion
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Blood Transfusion
, pRBC, Packed Red Blood Cells
See Also
Transfusion Complication
Transfusion Hemolysis
Preparations
Packed Red Blood Cells are derived from whole blood by removing 250 ml plasma
Most centers filter
Leukocyte
s before storage
Decreases
Febrile Nonhemolytic Transfusion Reaction
risk
CMV-safe
Indications
Acute
Sickle Cell Crisis
(
CVA Prevention
)
Massive acute blood loss >1500 ml (30% of
Blood Volume
)
Hemoglobin
<7.0 g/dl and no serious comorbidity (and no ongoing bleeding)
Hemoglobin
<9.0 g/dl with serious comorbidity (e.g. cardiovascular disease, active bleeding)
Symptomatic
Anemia
Severe
Fatigue
, weakness, or
Dizziness
Dyspnea
Altered Level of Consciousness
Angina
Congestive Heart Failure
Hospitalized patient criteria (per American Association of Blood Banks)
Hemoglobin
<7 mg/dl if hemodynamically stable (even if critically ill)
Hemoglobin
<8 mg/dl if orthopedic surgery, cardiac surgery or preexisting
Coronary Artery Disease
Unclear threshold for
Acute Coronary Syndrome
, severe
Thrombocytopenia
, chronic transfusion-dependent
Anemia
Labs
Hemoglobin
Expect one unit pRBC to raise
Hemoglobin
by 1 g/dl
Hematocrit
Expect one unit pRBC to raise
Hematocrit
by 3%
Adverse Effects
See
Transfusion Hemolysis
(
Immune Transfusion Reaction
)
See
Transfusion Complication
References
Klein (2007) Lancet 370(9585): 415-26 [PubMed]
Sharma (2011) Am Fam Physician 83(6): 719-24 [PubMed]
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