Lab

Erythrocyte Morphology on Peripheral Smear

search

Erythrocyte Morphology on Peripheral Smear, Erythrocyte Morphology, Red Blood Cell Morphology, Macrocyte, Microcyte, Spherocyte, Elliptocyte, Schistocyte, Acanthocyte, Spur Cell, Dacryocyte, Howell-Jolly, Target Cell, Basophilic Stippling, Sideroblast, Cabot's Ring Bodies

  • Background
  1. Variants below as seen on Peripheral Smear
  2. RBC Evaluation parameters
    1. RBC Color
    2. RBC Size
    3. RBC Shape
    4. RBC Contents
  • Causes
  • Macrocytes
  • Causes
  • Spherocytes
  1. Hereditary Spherocytosis
  2. Autoimmune Hemolytic Anemia
  3. Acute Alcoholism
  4. Hemoglobin C Disease
  5. Following severe Burn Injury
  6. Hemolytic Transfusion Reactions
  7. Severe Hypophosphatemia
  8. Acute Oxidant Injury: Hexose Monophosphate Shunt Defect
  9. Clostridium Welchii Septicemia
  • Causes
  • Elliptocytes (Oval Cells)
  1. Megaloblastic Anemia
  2. Myelofibrosis
  3. Refractory normoblastic Anemia
  4. Hereditary elliptocytosis
  5. Thalassemia
  • Causes
  • Dacryocytes (tear drop RBC)
  1. Extramedullary hemopoiesis
  2. Myelophthisic Anemia
  3. Severe Hemolytic Anemia
  4. Erythroleukemia
  • Causes
  • Acanthocytes (Spur Cells)
  1. Abetalipoproteinemia
  2. Cirrhosis
  3. Hepatic necrosis
  4. Pyruvate kinase deficiency
  5. Uremia
  6. Infantile pyknocytosis
  • Causes
  • Howell-Jolly Bodies
  • Causes
  • Basophilic Stippling (aggregated ribosomes)
  1. Lead Poisoning
  2. Arsenic Poisoning
  3. Thalassemia
  4. Sideroblastic Anemia
  5. Hemolytic Anemia
  6. Severe Anemia
  7. Unstable Hemoglobin
  8. Pyrimidine 5'-Nucleotidase Deficiency
  • Causes
  • Heinz Body (Aggregates of denatured Hemoglobin)
  • Causes
  • Target Cells
  • Causes
  • Sideroblasts
  1. See Sideroblastic Anemia
  2. Nucleated RBCs
  3. Iron laden mitochondria
  • Causes
  • Cabot's Ring Bodies (Nuclear remnants)
  • Causes
  • Other findings on RBC exam
  • References
  1. Ravel (1995) Clinical Laboratory Medicine, p. 14-16