Hemoglobin

Hereditary Spherocytosis

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Hereditary Spherocytosis, Minkowski-Chauffard syndrome

  • Pathophysiology
  1. Most common inherited membranopathy
  2. Results from membrane protein gene mutations
  3. Autosomal Dominant
  • Labs
  • Confirmation
  1. Osmotic Fragility
  2. Eosin-5-Maleimide Binding
  • Management
  1. Splenectomy
    1. Indicated in moderate to severe cases
  • Complications